Stereology: A practical primer for neuropathology
Stereology: A practical primer for neuropathology
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DOI：
10.1097/00005072-199804000-00001
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发表时间：
1998-04-01
影响因子：
3.2
通讯作者：
Irizarry, MC
中科院分区：
文献类型：
--
作者：
Hyman, BT;Gomez-Isla, T;Irizarry, MC
近年来，一种被称为立体学的方法已经开始主导定量神经病理学和解剖学研究，以至于一些期刊的社论提倡使用立体学计数方案而不是其他定量评估方法（1,2）。我们在这篇综述的目的是检查应用立体学方法在神经病理学的实际问题的优点和缺点。立体学是一套规则系统，旨在克服计算幻灯片上物体（如神经元）时固有的真实和感知问题(3)。有许多特定的工具属于“立体学”，每个工具都是为了解决特定的问题而设计的。我们将集中讨论那些主要用于神经元计数的工具——光学指示器和相关方法——因为这些可能是神经病理学家的主要兴趣。最近发表了对这些方法和诸如分馏器等其他补充技术的详细评论（4,5）。
In recent years, a methodology known as stereology has come to dominate quantitative neuropathological and anatomical studies, to the point where editorials in several journals promote the use of stereological counting schemes over other methods of quantitative assessment (1, 2). Our goal in this review is to examine the advantages and disadvantages of applying stereological approaches to practical problems in neuropathology.Stereology is a system of rules designed to overcome real and perceived problems inherent in counting objects (eg neurons) on a slide (3). There are many specific tools that fall under" stereology," each designed to solve particular problems. We will focus on those tools used primarily for neuron counting-the optical disector and related methods-because these may be of primary interest to neuropathologists. Detailed reviews of these methods and of other complementary techniques such as the fractionater have been recently published (4, 5).