REGULATION OF BRONCHOMOTOR TONE BY LUNG-INFLATION IN ASTHMATIC AND NON-ASTHMATIC SUBJECTS
REGULATION OF BRONCHOMOTOR TONE BY LUNG-INFLATION IN ASTHMATIC AND NON-ASTHMATIC SUBJECTS
复制标题
DOI：
10.1152/jappl.1981.50.5.1079
复制
发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
PETERMAN, VI
中科院分区：
文献类型：
--
作者：
FISH, JE;ANKIN, MG;PETERMAN, VI
本文观察了14例特应性哮喘和14例特应性非哮喘受试者肺充气对诱导气道阻塞的影响。受试者用乙酰甲胆碱(MCH)和花粉抗原(Ag)气雾剂激发，通过部分和全流量-容量曲线以及通过比较深吸气前后的气道电导测量总肺活量(TLC)来评估充气的效果。在非哮喘患者中，吸气时，支气管收缩会暂时消失或减弱，而在哮喘患者中，这些效应则不存在或减弱。差异不能用基线肺功能或产生的梗阻程度的差异来解释。在非哮喘患者中，深吸入法对减少MCH引起的呼吸道阻塞的作用大于用银剂。阿托品预处理对吸入Ag的哮喘患者的吸气反应无影响，提示迷走神经反射不是肺充气引起的降低支气管运动张力能力受损的原因。通过肺容量的主动变化，揭示了调节支气管运动张力的内在手段的存在，而这种机制在哮喘中受到损害。哮喘患者的气道高反应性与其说是终末器官反应增强的反映，不如说是这种能力受损的反映。
The effects of lung inflation on induced airway obstruction was examined in 14 atopic asthmatic and 14 atopic nonasthmatic subjects. Subjects were challenged with aerosols of methacholine (MCh) and pollen antigen (Ag), and the effects of inflation were assessed with partial and full flow-volume curves and by comparing airway conductance measurements before and after deep inspiration to total lung capacity (TLC). Whereas bronchoconstriction was transiently abolished or reduced with inspiration in nonasthmatics, these effects were absent or diminished in asthmatic subjects. Dissimilarities could not be explained by differences in base-line lung function or degree of obstruction produced. Deep inspiration had a greater effect in reducing airway obstruction produced with MCh than with Ag in nonasthmatics. Atropine pretreatment had no effect on inspiration responses in asthmatics given Ag, suggesting that vagal reflexes were not the cause of an impaired ability to reduce bronchomotor tone by lung inflation. The existence is revealed of an intrinsic means of regulating bronchomotor tone by active changes in lung volume and such a mechanism is impaired in asthma. Airway hyperreactivity in asthma is perhaps less a reflection of enhanced end-organ responsivensss than a reflection of this impaired capacity.