A nosocomial sapovirus-associated outbreak of gastroenteritis in adults
A nosocomial sapovirus-associated outbreak of gastroenteritis in adults
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DOI：
10.1080/00365540410020974
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发表时间：
2005-03-01
影响因子：
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通讯作者：
Hedlund, KO
中科院分区：
文献类型：
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作者：
Johansson, PJH;Bergentoft, K;Hedlund, KO
人类杯状病毒、诺如病毒和萨波病毒是急性非细菌性胃肠炎的主要病因。与诺如病毒不同，萨帕病毒已知主要在婴儿和幼儿中引起感染。我们描述了一起与萨波病毒相关的肠胃炎的院内暴发，涉及23名成年患者和医务人员。患者和医务人员的平均年龄为52岁，主要体征和症状为恶心、腹泻、呕吐、腹部痉挛、头痛、肌痛和发烧。腹泻患者（72%）多于呕吐患者（56%），平均症状持续时间为6天。10例平均年龄29岁的患者中，继发发病率为45%。衣壳基因序列显示，与IV基因组参考株千叶/000671T/1999有97%的核苷酸同源性。这是首次报道的成人sapovirus感染的院内暴发之一，表明在成人肠胃炎的调查中应包括sapovirus的诊断测试。
The human caliciviruses norovirus and sapovirus are leading causes of acute, non-bacterial gastroenteritis. In contrast to norovirus, sapovirus is known to give infections mainly in infants and young children. We describe a nosocomial outbreak of gastroenteritis associated with sapovirus involving 23 adult patients and medical staff. The mean age of the patients and medical staff was 52 y and the major signs and symptoms were nausea, diarrhoea, vomiting, abdominal cramp, headache, myalgia and fever. More patients had diarrhoea (72%) than vomiting (56%) and the mean duration of symptoms was 6 d. A secondary attack rate of 45% was seen affecting in all 10 persons with a mean age of 29 y. Sequences of the capsid gene revealed a 97% nucleotide homology to the sapovirus genogroup IV reference strain Chiba/000671T/1999. This is one of the first reported nosocomial outbreaks of sapovirus infection among adults and shows that a diagnostic test for sapovirus should be included in investigation of gastroenteritis among adults.