Three-drug combination chemotherapy for advanced urothelial tract carcinoma
Three-drug combination chemotherapy for advanced urothelial tract carcinoma
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三药联合化疗治疗晚期尿路上皮癌
DOI：
10.1007/bf00262479
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发表时间：
2004
影响因子：
3
通讯作者：
Y. Aso
中科院分区：
文献类型：
--
作者：
S. Ohshima;Y. Ono;T. Fujita;Y. Aso
1981年4月至1986年8月，对24例晚期尿路移行细胞癌患者进行了一项前瞻性化疗试验，采用三种不同方案的三种药物联合治疗。所有患者均有组织学证实的移行细胞癌和可测量的二维病变。方案1 （PPA）为5天疗程，第1 - 5天使用20 mg/m2顺铂和5 mg/m2培霉素（博来霉素的衍生物），第1天使用25 mg/m2阿霉素。方案II （CFMit）为10天疗程，第1天使用3 mg/m2丝裂霉素c和300 mg/m2环磷酰胺，第1 - 10天使用180 mg/m2 5-氟尿嘧啶。方案III （PAM）是一个为期1天的疗程，包括60 mg/m2顺铂、30 mg/m2阿霉素和40 mg/m2甲氨蝶呤。在方案I和III中，药物每4-5周给药一次，而在方案II中，药物连续给药，没有任何间隔。在接受1 ~ 5个疗程PPA治疗的9例患者中，只有3例患者出现轻微反应。在接受4 - 44个疗程CFMit治疗的10例患者中，3例（33%）获得了1.5-22个月的部分缓解，3例有轻微反应。在接受3 - 7个PAM疗程的5例患者中，1例患者达到部分缓解5个月，1例患者有轻微反应。骨髓抑制、恶心、呕吐和厌食在每个方案中都经常被观察到。在方案一和方案三中经常观察到脱发。方案二观察到口炎和腹泻。方案1中有3例患者，方案2中有4例患者，方案3中有1例患者由于严重的副作用无法耐受更多疗程的方案。
SummaryA prospective chemotherapeutic trial using combinations of three drugs consisting of three different protocols was performed in 24 patients with advanced transitional-cell carcinoma of the urothelial tract between April 1981 and August 1986. All patients had histologically proven transitional-cell carcinoma and bidimensionally measurable lesions. The protocol I (PPA) was a 5-day course of treatment with 20 mg/m2 cis-platinum and 5 mg/m2 peplomycin (a derivative of bleomycin) on days 1–5, and 25 mg/m2 adriamycin on day 1. Protocol II (CFMit) was a 10-day course with 3 mg/m2 mitomycin-C and 300 mg/m2 cyclophosphamide on day 1, and 180 mg/m2 5-fluorouracil on days 1–10. Protocol III (PAM) was a 1-day course comprising 60 mg/m2 cis-platinum, 30 mg/m2 adriamycin, and 40 mg/m2 methotrexate. In protocols I and III, the drugs were administered every 4–5 weeks, while in protocol II, the drugs were administered continuously without any interval. Of the 9 patients who received 1 to 5 PPA courses, only 3 patients showed a minor response. In the 10 patients who received 4 to 44 CFMit courses, 3 (33%) achieved partial remission for 1.5–22 months, and 3 had a minor response. Of the 5 patients receiving 3 to 7 PAM courses, 1 patient achieved partial remission for 5 months, and 1 had a minor response. Myelosuppression, nausea, vomiting, and anorexia were frequently observed in each protocol. Loss of hair was often observed in protocols I and III. Stomatitis and diarrhea were observed in protocol II. Three patients in protocol I, 4 patients in protocol II, and 1 patient in protocol III were unable to tolerate more courses of the regimen due to the severe side effects.
尿路上皮肿瘤患者的 II 期试验。
影响因子：
3
作者：
Yagoda,A
通讯作者：
Yagoda,A
影响因子：
6.6
作者：
STERNBERG, CN;YAGODA, A;WHITMORE, WF
通讯作者：
WHITMORE, WF
顺铂、环磷酰胺和阿霉素连续给药治疗尿路上皮肿瘤的 II 期试验。
DOI：
10.1016/s0022-5347(17)51401-9
发表时间：
1983
期刊：
The Journal of urology
影响因子：
--
作者：
Schwartz,S;Yagoda,A;Natale,RB;Watson,RC;Whitmore,WF;Lesser,M
通讯作者：
Lesser,M