Age-related changes in plasma levels of BDNF in Down syndrome patients.
Age-related changes in plasma levels of BDNF in Down syndrome patients.
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DOI：
10.1186/1742-4933-7-2
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发表时间：
2010-01-25
期刊：
影响因子：
--
通讯作者：
Corsi, Massimiliano M
中科院分区：
文献类型：
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作者：
Dogliotti, Giada;Galliera, Emanuela;Corsi, Massimiliano M
背景：唐氏综合征(DS)患者中冠状动脉疾病的患病率很低，他们很少死于动脉粥样硬化并发症。目的：探讨唐氏综合征(DS)患者年龄与脑源性神经营养因子(BDNF)水平的关系。目的：探讨唐氏综合征(DS)患者年龄与脑源性神经营养因子水平的关系。结果：DS患者血浆BDNF水平明显高于对照组，且随年龄增长而显著增加。血清IL-6和MCP-1水平在DS儿童和成人中也高于健康对照组，但在老年患者中并不高于健康对照组。高水平的循环BDNF可能对DS患者动脉粥样硬化的临床并发症具有保护作用。然而，随着年龄的增长，外周血中BDNF水平的显著下降可能使这些患者在晚年更容易出现痴呆的临床表现。
BACKGROUND: The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis, or even a total lack of atherosclerotic changes, in DS AIM: The aim of our study is to investigate the relationship between age and brain-derived neurotrophic factor (BDNF) levels in Down Syndrome (DS).SUBJECTS AND METHODS: Three groups of DS patients were studied: the first consisted of 23 children (age 2-14 years); the second of 14 adults (age 20-50 years), the third group of 13 elderly persons (>60 years) and a controls group of 20 healthy patients (age 15-60 years).The analytes of interest were quantified using a biochip array analyzer (Evidence, Randox Ltd., Crumlin, UK).RESULTS: Plasma BDNF was higher in DS patients than in controls and there was a significant age-related increase. Serum levels of IL-6 and MCP-1 were also higher in DS children and adults, but not in older patients, than in healthy control. High levels of circulating BDNF may protect DS patients from the clinical complications of atherosclerosis. However, the striking drop in peripheral BDNF levels with age might predispose these patients to clinical manifestations of dementia in later life.