The Roles of Interferon Regulatory Factors 1 and 2 in the Progression of Human Pancreatic Cancer
The Roles of Interferon Regulatory Factors 1 and 2 in the Progression of Human Pancreatic Cancer
复制标题
DOI：
10.1097/mpa.0000000000000116
复制
发表时间：
2014-08-01
期刊：
影响因子：
2.9
通讯作者：
Ohnishi, Hirohide
中科院分区：
文献类型：
--
作者：
Sakai, Toshitaka;Mashima, Hirosato;Ohnishi, Hirohide
目的：胰腺癌是世界范围内最常见的恶性肿瘤之一。干扰素调节因子（IRF）1和IRF 2在几种类型的癌症中分别作为肿瘤抑制因子和癌蛋白发挥作用。方法：检测IRF1和IRF2在胰腺癌组织中的表达，并分析其与胰腺癌临床病理特征的关系。结果：IRF1和IRF2在胰腺癌细胞中的表达水平分别较正常对照组降低和升高。IRF1的高表达与肿瘤分化、浸润深度、肿瘤大小和生存率的较好特征相关，而IRF2的高表达与肿瘤浸润深度的较差特征相关。干扰素调节因子2过表达的PANC-1细胞表现出细胞生长增加，凋亡特征减少，对吉西他滨治疗产生耐药性。相反，IRF1过表达的细胞表现出相反的characteristics.Conclusions：干扰素调节因子1和2可以调节胰腺癌的进展，作为一种抗癌蛋白和癌蛋白，分别发挥作用。这些分子可以作为潜在的治疗靶点。
Objective: Pancreatic cancer is one of the most malignant diseases worldwide. Interferon regulatory factor (IRF) 1 and IRF2 function as a tumor suppressor and oncoprotein, respectively, in several types of cancers. We investigated whether IRF1 and IRF2 are involved in the progression of pancreatic cancer.Methods: We examined the expressions of IRF1 and IRF2 in pancreatic cancer specimens and analyzed the association with clinicopathologic features. We evaluated the biological effects of IRF1 and IRF2 using a pancreatic cancer cell line.Results: The expression levels of IRF1 and IRF2 were decreased and increased, respectively, in the pancreatic cancer cells compared with those observed in the paired normal areas. A higher expression of IRF1 was associated with better features of tumor differentiation, infiltration depth, tumor size, and survival, whereas that of IRF2 was associated with a worse feature of tumor infiltration depth. Interferon regulatory factor 2-overexpressing PANC-1 cells exhibited an increase in cell growth, less apoptotic features, and chemoresistance to gemcitabine treatment. In contrast, IRF1-overexpressing cells exhibited the opposite characteristics.Conclusions: Interferon regulatory factors 1 and 2 may regulate the progression of pancreatic cancer by functioning as an antioncoprotein and oncoprotein, respectively. These molecules may serve as potential targets of therapy.