GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung
GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung
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DOI：
10.1097/pas.0000000000000825
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发表时间：
2017-09-01
影响因子：
5.6
通讯作者：
Churg, Andrew
中科院分区：
文献类型：
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作者：
Berg, Kyra B.;Churg, Andrew
肉瘤样和促结缔组织增生性恶性间皮瘤与转移到胸膜的肉瘤样癌的分离可能是困难的，因为这两种类型的肿瘤可以在形态学上相似，并且通常仅对泛角蛋白呈阳性。加塔结合蛋白3（GATA 3）是最常用的乳腺癌和尿路上皮癌的免疫组织化学标记物，但也被称为染色其他类型的肿瘤，包括一些间皮瘤。在这项研究中，我们询问GATA 3染色是否可以用于区分肺肉瘤样癌（N = 13）肉瘤样/促结缔组织增生性恶性间皮瘤（N = 19）。对肿瘤染色的扩散度和强度进行评分，最高评分为6分。所有19例肉瘤样/促结缔组织增生性恶性间皮瘤检查显示GATA 3强弥漫染色（无病例评分
The separation of sarcomatoid and desmoplastic malignant mesotheliomas from sarcomatoid carcinomas of the lung metastatic to the pleura may be difficult, since both types of tumor can be morphologically similar and are frequently positive only for pan-keratin. GATA binding protein 3 (GATA3) is most commonly used as an immunohistochemical marker of breast and urothelial carcinoma, but is also known to stain other types of tumors including some mesotheliomas. In this study we asked whether GATA3 stains could be used to distinguish sarcomatoid/desmoplastic malignant mesotheliomas (N=19) from sarcomatoid carcinomas of the lung (N=13). Tumor staining was scored for diffuseness and intensity, with a maximum possible score of 6. All 19 sarcomatoid/desmoplastic malignant mesotheliomas examined showed strong diffuse staining for GATA3 (no case scored