Malaria
Malaria
复制标题
DOI：
10.1016/j.cll.2009.10.001
复制
发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Garcia, Lynne S.
中科院分区：
文献类型：
--
作者：
Garcia, Lynne S.
疟疾对世界历史的影响比任何其他传染病都大。全世界有3亿至5亿人感染疟原虫，每年有150万至270万人死于这种感染，其中大多数是儿童。疟疾在90多个国家流行，其中有24亿人生活;这代表了世界人口的40%。大约90%的疟疾死亡发生在非洲。尽管在疫苗开发方面不断努力，但疟疾预防仍然困难，而且没有任何药物是普遍有效的。本文研究了由感染人类的4种最常见的疟原虫引起的疟疾，即间日疟原虫、卵形疟原虫、三日疟原虫和恶性疟原虫，以及混合感染和猿寄生虫诺氏疟原虫。对这些形式的疟疾的微生物学、临床表现、发病机制、诊断和治疗进行了全面的回顾。
Malaria has had a greater impact on world history than any other infectious disease. More than 300 to 500 million individuals worldwide are infected with Plasmodium spp, and 1.5 to 2.7 million people a year, most of whom are children, die from the infection. Malaria is endemic in over 90 countries in which 2400 million people live; this represents 40% of the world's population. Approximately 90% of malaria deaths occur in Africa. Despite continuing efforts in vaccine development, malaria prevention is difficult, and no drug is universally effective. This article examines malaria caused by the 4 most common Plasmodium spp that infect humans, P vivax, P ovale, P malariae, and P falciparum, as well as mixed infections and the simian parasite P knowlesi. A comprehensive review of the microbiology, clinical presentation, pathogenesis, diagnosis, and treatment of these forms of malaria is given.