Dimeric inhibin a as a marker for Down's syndrome in early pregnancy
Dimeric inhibin a as a marker for Down's syndrome in early pregnancy
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DOI：
10.1056/nejm199605093341904
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发表时间：
1996-05-09
影响因子：
158.5
通讯作者：
Connor, JM
中科院分区：
文献类型：
--
作者：
Aitken, DA;Wallace, EM;Connor, JM
背景在妊娠中期筛查唐氏综合征时，孕妇血清中甲胎蛋白、人绒毛膜促性腺激素β亚单位和完整人绒毛膜促性腺激素的浓度是广泛使用的标志物。我们研究了一种新的标记物，二聚体的阿糖胞苷A，并比较其预测价值与已建立的标记物。从58名已知胎儿受唐氏综合征影响的妇女、32名胎儿受18三体影响的妇女和438名胎儿正常的妇女中在妊娠7至18周时获得血清样品，并分析样品的每种标记物。在正常妊娠妇女中，每种标记物的个体血清浓度在适当的妊娠期被转换为中位数的倍数，通过多变量分析估计唐氏综合征的检出率，通过筛查与其他标记物的各种组合来检测唐氏综合征。唐氏综合征孕妇血清中BABIN A浓度是正常孕妇中位数的2.06倍（P
Background. In screening for Down's syndrome in the second trimester of pregnancy, the concentrations of alpha-fetoprotein, the beta subunit of human chorionic gonadotropin, and intact human chorionic gonadotropin in maternal serum are widely used markers. We investigated a new marker, dimeric inhibin A, and compared its predictive value with that of the established markers.Methods. Serum samples were obtained at 7 to 18 weeks of gestation from 58 women whose fetuses were known to be affected by Down's syndrome, 32 whose fetuses were affected by trisomy 18, and 438 whose fetuses were normal, and the samples were analyzed for each marker. Individual serum concentrations of each marker were converted to multiples of the median value at the appropriate length of gestation in the women with normal pregnancies, and rates of detection of Down's syndrome by screening for inhibin A in various combinations with the other markers were estimated by multivariate analysis.Results. In the women with fetuses affected by Down's syndrome, the serum inhibin A concentrations were 2.06 times the median value in the women with normal pregnancies (P