ROLE OF ENDOTHELIN-1 AND THE ET(A) RECEPTOR IN THE MAINTENANCE OF DEOXYCORTICOSTERONE ACETATE-SALT-INDUCED HYPERTENSION
ROLE OF ENDOTHELIN-1 AND THE ET(A) RECEPTOR IN THE MAINTENANCE OF DEOXYCORTICOSTERONE ACETATE-SALT-INDUCED HYPERTENSION
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DOI：
10.1111/j.1476-5381.1995.tb13292.x
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发表时间：
1995-03-01
影响因子：
7.3
通讯作者：
MORIMOTO, S
中科院分区：
文献类型：
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作者：
FUJITA, K;MATSUMURA, Y;MORIMOTO, S
1为探讨内皮素-1(ET-1)在脱氧皮质酮-醋酸酯(DOCA)-盐性高血压大鼠血管和肾组织中的作用，我们检测了DOCA-盐性高血压大鼠血管和肾组织中ET-I的浓度变化，并评价了ET(A)受体拮抗剂FR139317的降压作用。DOCA-盐性高血压大鼠肾脏ET-1水平无明显变化。3 DOCA-盐性高血压大鼠肾组织ET-1水平与正常对照组比较，差异有统计学意义(r=0.83，P
1 To search for a possible role for endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, we examined changes in concentration of ET-I in vascular and renal tissue in DOCA-salt hypertensive rats and evaluated the antihypertensive effect of the ET(A) receptor antagonist, FR139317.2 There was an increase in aortic immunoreactive-ET (IR-ET) concentrations in association with hypertension-induced treatment. There were no significant changes in ET-1 levels in the kidney with DOCA-salt treatment.3 In DOCA-salt hypertensive rats, a significant correlation (r=0.83, P