Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica
Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica
复制标题
金银花花蕾中吡啶生物碱偶联的环烯醚萜类化合物
DOI：
10.1021/np800040k
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发表时间：
2008-05-01
影响因子：
5.1
通讯作者：
Shi, Jiangong
中科院分区：
文献类型：
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作者：
Song, Weixia;Li, Shuai;Shi, Jiangong
从忍冬（Lonicera japonica）花蕾中分离出了三种吡啶类内盐生物碱，即lonijaposides a - c(1-3)，它们是基于一个n -取代烟酸核通过C-5与环烯醚萜C-7偶联的前所未有的骨架，以及七个已知的环烯醚萜。通过光谱和化学分析对其结构进行了鉴定。龙葵皂苷C(3)对血小板活化因子诱导的大鼠多形核白细胞葡萄糖醛酸酶释放有抑制作用。
Three pyridinium inner salt alkaloids, lonijaposides A-C (1-3), based on an unprecedented skeleton of an N-substituted nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid, together with seven known iridoids, have been isolated from the flower buds of Lonicera japonica. Their structures were elucidated by spectroscopic and chemical analyses. Lonijaposide C (3) showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor.