Granulocyte colony-stimulating factor administered in vivo augments neutrophil-mediated activity against opportunistic fungal pathogens
Granulocyte colony-stimulating factor administered in vivo augments neutrophil-mediated activity against opportunistic fungal pathogens
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DOI：
10.1086/513961
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发表时间：
1997-04-01
影响因子：
6.4
通讯作者：
Dale, DC
中科院分区：
文献类型：
--
作者：
Liles, WC;Huang, JE;Dale, DC
粒细胞集落刺激因子（G-CSF）不仅可以增加中性粒细胞（多形核白细胞，PMNL）的产生，还可以调节 PMNL 的生物学功能。为了评估体内给予 G-CSF 增强 PMNL 对抗机会性真菌病原体活性的能力，比较了正常人志愿者在给予 G-CSF 之前和之后获得的 PMNL 的抗真菌活性。在体内，G-CSF 显着增强 PMNL 介导的对烟曲霉和根霉的杀灭作用，分别提高了 4 倍和 15 倍（P
Granulocyte colony-stimulating factor (G-CSF) not only increases neutrophil (polymorphonuclear leukocyte, PMNL) production but also modulates PMNL biologic function, To assess the ability of G-CSF administered in vivo to enhance PMNL activity against opportunistic fungal pathogens, the antifungal activity of PMNL obtained from normal human volunteers before and after G-CSF administration was compared. In vivo, G-CSF significantly enhanced PMNL-mediated killing of Aspergillus fumigatus and Rhizopus arrhizus by 4-fold and 15-fold, respectively (P