Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models
Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models
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DOI：
10.1097/ico.0000000000001717
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发表时间：
2018-09
期刊：
影响因子：
2.8
通讯作者：
T. Sakimoto
中科院分区：
文献类型：
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作者：
T. Sakimoto
摘要：危险相关的分子模式，如组织损伤后释放到细胞外或暴露在细胞表面的核蛋白或胞浆蛋白，以及病原体相关的分子模式，如脂多糖、肽聚糖和核酸，都会刺激一种称为炎症体的大型蛋白质复合体的形成。炎性小体是由3种蛋白质组成的胞浆复合体，裂解并释放白细胞介素1。最近的研究已经确定了大量内源性和外源性的炎症体配体。此外，使用不同的动物模型，炎症性小体在人类疾病中的意义已经被阐明为多方面的疾病，如代谢综合征、炎症性肠病、阿尔茨海默病和某些炎症性皮肤病。本文综述了其中的几种情况，并讨论了炎症小体受累的不同模型，包括角膜的动物模型。
Abstract: Danger-associated molecular patterns, such as nuclear or cytosolic proteins released outside the cell or exposed on the cell surface after tissue injury, and pathogen-associated molecular patterns, such as lipopolysaccharide, peptidoglycan, and nucleic acid, stimulate the formation of a large protein complex called the inflammasome. The inflammasome is a cytosolic complex of 3 proteins that cleaves and releases interleukin-1. Recent studies have characterized a multitude of inflammasome ligands of both endogenous and exogenous origins. Moreover, using various animal models, the implications of inflammasomes in human diseases have been elucidated for multifaceted diseases such as metabolic syndrome, inflammatory bowel disease, Alzheimer disease, and certain inflammatory skin diseases. This article reviews several of these conditions and discusses the different models proposed for inflammasome involvement, including animal models of the cornea.