Role of Biological Agents in Immune-mediated Inflammatory Diseases
Role of Biological Agents in Immune-mediated Inflammatory Diseases
复制标题
生物制剂在免疫介导的炎症性疾病中的作用
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
J. Markenson
中科院分区：
文献类型：
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作者：
P. Efthimiou;J. Markenson
随着抗细胞因子疗法的临床应用，免疫介导的炎症性疾病治疗的新时代已经开始。目前可用的生物制剂包括 3 种降低肿瘤坏死因子-α 活性的药物（英夫利昔单抗、阿达木单抗、依那西普）和白细胞介素 1 受体拮抗剂（阿那白滞素），还有更多药物正在开发中。这些非常有效的药物是我们治疗装备的重要补充，虽然最初是为类风湿性关节炎和克罗恩病开发的，但已被发现可有效治疗血清阴性脊柱关节病（银屑病关节炎、强直性脊柱炎）和幼年类风湿性关节炎。目前正在确定它们在其他自身免疫性疾病中的作用，例如葡萄膜炎、结节病、间质性肺病、血管炎、炎性肌病、移植物抗宿主病和干燥综合征。
A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-α (infliximab, adalimumab, etanercept) and an interleukin-1 receptor antagonist (anakinra), with many more in development. Those extraordinarily effective medications are an important addition to our therapeutic armamentarium, and, although originally developed for rheumatoid arthritis and Crohn disease, have been found to be efficacious in the treatment of seronegative spondyloarthropathies (psoriatic arthritis, ankylosing spondylitis) and juvenile rheumatoid arthritis. Their role is currently being defined in other autoimmune disorders such as uveitis, sarcoidosis, interstitial lung disease, vasculitis, inflammatory myopathies, graft-versus-host disease, and Sjögren syndrome.
影响因子：
158.5
作者：
Gorman, JD;Sack, KE;Davis, JC
通讯作者：
Davis, JC