Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
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DOI：
10.2337/diacare.25.6.989
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发表时间：
2002-06-01
期刊：
影响因子：
16.2
通讯作者：
Wilson, PWF
中科院分区：
文献类型：
--
作者：
Schaefer, EJ;McNamara, JR;Wilson, PWF
目的-富含磷脂酰肌醇的脂蛋白被认为是致动脉粥样硬化的。一种新的基于抗体的测定允许从血浆或血清中分离残粒样颗粒（RLP），并随后测量RLP胆固醇（RLPC）和甘油三酯（RLPTG）。我们假设糖尿病患者的RLPC和RLPTG水平高于非糖尿病患者。设计和方法-我们比较了糖尿病受试者的RLPC和RLPTG水平（68名女性，121名男性）与非糖尿病受试者一起参加了心脏病研究。（1 499名妇女，1名，结果-糖尿病女性的平均RLPC值比非糖尿病女性高106（0.367 +/- 0.546 mmol/l [14.2 +/- 21.1 mg/dl] vs. 0.179 +/- 0.1.09 mmol/l 16.9 +/- 14.2 mg/dl]; P < 0.0001），糖尿病妇女的RLPTG值比非糖尿病妇女高38.5（1.089 +/- 2.775 mmol/l [93.1 +/- 245.6 mg/dl]对比0.217 +/- 0.235 mmol/l [19.2 +/- 20.8 mg/dl]; P < 0.0001）。在糖尿病男性中观察到类似但不太显著的差异，他们的平均RLPC值比非糖尿病男性高28（0.285 +/- 0.261 mmol/l [11.0 +/- 10.1 mg/dl] vs. 0.223 +/- 0.163 mmol/l [8.6 +/- 6.3 mg/dl]; P < 0.001），平均RLPTG值比非糖尿病男性高70%（0.606 +/- 1.019 mmol/l [53.6 +/- 90.2 mg/dl]对比0.357 +/- 0.546 mmol/l [31.6 +/- 48.3 mg/dl] P < 0.001）。此外，糖尿病男性和女性有显着较高的总甘油三酯和较低的HDL胆固醇水平比nondiabetic subjects.CONCLUSIONS -数据表明，RLP颗粒升高糖尿病受试者。为了达到最佳的降低心血管疾病的风险，应考虑治疗RLP值升高，沿着控制LDL胆固醇水平。
OBJECTIVE - Remnants of triglyceride-rich lipoproteins are thought to be atherogenic. A new antibody-based assay allows for the isolation of remnant-like particles (RLPs) from plasma or serum, and the subsequent measurement of RLP cholesterol (RLPC) and triglycerides (RLPTGs). We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients.DESIGN AND METHODS - We compared RLPC and RLPTG levels of diabetic subjects (68 women, 121 men) participating in the Framingham Heart Study with those of nondiabetic subjects (1,499 women, 1,357 men).RESULTS - Mean RLPC values for diabetic women were 106% higher than those for nondiabetic women (0.367 +/- 0.546 mmol/l [14.2 +/- 21.1 mg/dl] vs. 0.179 +/- 0.1.09 mmol/l 16.9 +/- 14.2 mg/dl]; P < 0.0001), and RLPTG values for diabetic women were 385% higher than those for nondiabetic women (1.089 +/- 2.775 mmol/l [93.1 +/- 245.6 mg/dl] vs. 0.217 +/- 0.235 mmol/l [19.2 +/- 20.8 mg/dl]; P < 0.0001). Similar but less striking differences were observed in diabetic men, who had mean RLPC values 28% higher than those seen in nondiabetic men (0.285 +/- 0.261 mmol/l [11.0 +/- 10.1 mg/dl] vs. 0.223 +/- 0.163 mmol/l [8.6 +/- 6.3 mg/dl]; P < 0.001) and mean RLPTG values 70% higher than those seen in nondiabetic men (0.606 +/- 1.019 mmol/l [53.6 +/- 90.2 mg/dl] vs. 0.357 +/- 0.546 mmol/l [31.6 +/- 48.3 mg/dl] P < 0.001). Moreover, diabetic men and women had significantly higher total triglycerides and lower HDL cholesterol levels than nondiabetic subjects.CONCLUSIONS - The data indicate that RLP particles are elevated in diabetic subjects. To achieve optimal reduction of risk for cardiovascular disease, treatment of elevated RLP values, along with the control of LDL cholesterol levels, should be considered.