Events at the Host-Microbial Interface of the Gastrointestinal Tract III. Cell-to-cell signaling among microbial flora, host, and pathogens: there is a whole lot of talking going on
Events at the Host-Microbial Interface of the Gastrointestinal Tract III. Cell-to-cell signaling among microbial flora, host, and pathogens: there is a whole lot of talking going on
复制标题
DOI：
10.1152/ajpgi.00572.2004
复制
发表时间：
2005-06-01
影响因子：
4.5
通讯作者：
Sperandio, V
中科院分区：
文献类型：
--
作者：
Clarke, MB;Sperandio, V
人类与其肠道微生物植物群有着重要的联系。微生物植物群有助于形成哺乳动物的先天免疫系统，吸收营养物质，并在肠道发育中起着复杂的作用。微生物和哺乳动物通过一系列激素和类激素化合物相互交流。然而，这些“信号”被细菌病原体劫持，如肠出血性大肠杆菌（EHEC），以激活其毒力基因，定殖宿主，并启动疾病过程。本文综述了肠出血性大肠杆菌在胃肠道中的细胞间信号传导，从而协调调节其毒力基因。
Humans have an important association with their intestinal microbial flora. The microbial flora helps to shape the mammalian innate immune system, absorbs nutrients, and plays an intricate role on intestinal development. Microbes and mammals communicate with each other through an array of hormone and hormonelike chemical compounds. These "signals," however, are hijacked by bacterial pathogens, such as enterohemorrhagic Eschrichia coli (EHEC), to activate its virulence genes, colonize the host, and start the disease process. This review explores the cell-to-cell signaling events in the gastrointestinal tract that lead EHEC to regulate its virulence genes in a coordinate manner.