Intrasurgical plasmin enzyme in diabetic macular edema.
Intrasurgical plasmin enzyme in diabetic macular edema.
复制标题
糖尿病黄斑水肿中的术中纤溶酶。
DOI：
10.1016/j.ajo.2004.05.024
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发表时间：
2004
影响因子：
4.2
通讯作者：
R. Brancato
中科院分区：
文献类型：
--
作者：
C. Azzolini;A. D’Angelo;G. Maestranzi;M. Codenotti;P. Della Valle;M. Prati;R. Brancato
目的：通过前瞻性研究评价术中自体纤溶酶（APE）治疗玻璃体后脱离的疗效。方法：对11例糖尿病性黄斑水肿继发于玻璃体后皮质收缩的患者12只眼进行回顾性分析。手术前25分钟，将0.1- 0.2-ml含有0.8 - 1.2 IU由我们的凝固服务制备的APE注射到玻璃体中。主观评价APE的有效性。对照组10只眼，具有相同的临床特征，接受相同的手术，不注射APE。完整的眼部检查，包括光学相干断层扫描，在手术前和1年的随访期间，所有患者进行了手术治疗组的手术过程中，后玻璃体皮质被判断为粘附在3例，部分分离在6例，完全分离在3例。在两例病例中，观察到玻璃体完全塌陷。在非APE治疗组的手术过程中，10只眼睛中有9只眼睛的后玻璃体皮质被判断为仍然粘连，1只眼睛部分脱离。比较APE治疗组和非APE治疗组的术后结果，我们发现最终术后视网膜厚度无显著差异（P = .2552），而我们发现最终视力有显著差异（P = .0121）。它似乎不干扰最终的视网膜厚度，并改善最终的视力。
PURPOSETo evaluate in a prospective study the efficacy of intrasurgical autologous plasmin enzyme (APE) in producing posterior vitreous detachment.DESIGNConsecutive, interventional case series.METHODSA group of 12 eyes of 11 patients with diabetic macular edema secondary to posterior vitreous cortex contraction was considered. A quantity of 0.1- to 0.2-ml containing 0.8 to 1.2 IU of APE prepared by our Coagulation Service was injected into the vitreous body 25 minutes before surgery. The efficacy of the APE was subjectively evaluated. A control group of 10 eyes with the same clinical characteristics underwent the same surgery without APE injection. Complete eye examinations, including optical coherence tomography, were performed on all patients before surgery and during the 1-year follow-up period.RESULTSDuring surgery in the APE-treated group, the posterior vitreous cortex was judged adherent in three cases, partially detached in six cases, and totally detached in three cases. In two cases a complete collapse of the vitreous body was observed. During surgery in the non–APE-treated group, the posterior vitreous cortex was judged still adherent in nine of 10 eyes and partially detached in 1 eye. Comparing the postoperative results between the APE-treated group and the non-APE-treated group, we found no significant differences in final postoperative retinal thickness (P = .2552), whereas we found a significant difference in final visual acuity (P = .0121).CONCLUSIONSAutologous plasmin enzyme was useful in inducing a pharmacologic posterior vitreous detachment and in facilitating surgery. It did not seem to interfere with the final retinal thickness, and it ameliorates the final visual acuity.
DOI：
10.1001/archopht.1993.01090060139038
发表时间：
1993
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Verstraeten,TC;Chapman,C;Hartzer,M;Winkler,BS;Trese,MT;Williams,GA
通讯作者：
Williams,GA