Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis
Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis
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实体器官移植后巨细胞病毒感染的预防：贝叶斯网络分析
DOI：
10.1186/s12941-020-00372-0
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发表时间：
2020-08
影响因子：
5.7
通讯作者：
Xia Qiang
中科院分区：
文献类型：
--
作者：
Zhang Yu;Zhou Tao;Huang Mingzhu;Gu Guangxiang;Xia Qiang
巨细胞病毒感染是实体器官移植术后最常见的并发症之一。目前已有几类抗病毒药物用于预防巨细胞病毒感染，如阿昔洛韦、伐昔洛韦、更昔洛韦和缬更昔洛韦。方法检索PubMed数据库中1984年1月至2018年3月的相关前瞻性和多臂研究。在巨细胞病毒感染的情况下，更昔洛韦组（OR = 0.24，95%CI 0.09-0.57）和伐昔洛韦组（OR = 0.20，95%CI 0.04-0.69）提供的结果明显优于对照组。更昔洛韦组（OR = 0.37，95%CI 0.13-0.86）和伐昔洛韦组（OR = 0.31，95%CI 0.07-0.98）与阿昔洛韦组相比显示出中度优势。在巨细胞病毒病方面，更昔洛韦组、伐昔洛韦组和缬更昔洛韦组均优于对照组（更昔洛韦组：OR = 0.17，95% CI 0.07-0.31;伐昔洛韦组：OR = 0.08，95% CI 0.01-0.33;缬更昔洛韦组：OR = 0.14，95% CI 0.02-0.45）。同样，更昔洛韦组（OR = 0.38，95%CI 0.12-0.71）和伐昔洛韦组（OR = 0.17，95%CI 0.03-0.72）比阿昔洛韦组显示更好的结果。需要进一步的研究来评估与伐昔洛韦给药相关的假定副作用。
BackgroundCytomegalovirus infection is one of the most common complications after solid organ transplantation. There have been several classes of antiviral drugs for the prevention of cytomegalovirus infection, such as acyclovir, valacyclovir, ganciclovir and valganciclovir.MethodsWe searched relevant prospective and multi-armed studies on PubMed from Jan. 1984 up to Mar. 2018.ResultsSeventeen prospective studies involving 2062 patients were included in the analysis. In the case of cytomegalovirus infection, the ganciclovir group (OR = 0.24, 95% CI 0.09–0.57) and the valacyclovir group (OR = 0.20, 95% CI 0.04–0.69) provided significantly better outcomes than the control group. The ganciclovir (OR = 0.37, 95% CI 0.13–0.86) and valacyclovir groups (OR = 0.31, 95% CI 0.07–0.98) showed moderate superiority compared to the acyclovir group. As for cytomegalovirus disease, the ganciclovir, valacyclovir and valganciclovir groups showed significant advantages compared with the control group (ganciclovir group: OR = 0.17, 95% CI 0.07–0.31, valacyclovir group: OR = 0.08, 95% CI 0.01–0.33, valganciclovir group: OR = 0.14, 95% CI 0.02–0.45). Similarly, the ganciclovir group (OR = 0.38, 95% CI 0.12–0.71) and the valacyclovir group (OR = 0.17, 95% CI 0.03–0.72) showed better results than the acyclovir group.ConclusionValacyclovir showed to be the most efficient antiviral for the prevention of cytomegalovirus infection and disease. Additional studies are required to evaluate putative side effects associated with valacyclovir administration.
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影响因子：
5.3
作者：
通讯作者：
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影响因子：
8.8
作者：
Razonable, R. R.;Humar, A.
通讯作者：
Humar, A.
DOI：
10.1093/ndt/gfg302
发表时间：
2003-09
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
S. Sagedal;K. Nordal;A. Hartmann;K. Midtvedt;A. Foss;A. Åsberg;M. Degré;P. Fauchald;H. Rollag-
通讯作者：
S. Sagedal;K. Nordal;A. Hartmann;K. Midtvedt;A. Foss;A. Åsberg;M. Degré;P. Fauchald;H. Rollag-
影响因子：
168.9
作者：
Gane, E;Saliba, F;Robinson, CA
通讯作者：
Robinson, CA
DOI：
10.1086/339449
发表时间：
2002-04
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
C. Payá;Jennie A. Wilson;M. Espy;I. Sia;Michael J. DeBernardi;T. F. Smith;Robin Patel;G. Jenkins-G.-Je
通讯作者：
C. Payá;Jennie A. Wilson;M. Espy;I. Sia;Michael J. DeBernardi;T. F. Smith;Robin Patel;G. Jenkins-G.-Je