The search for natural bioactive compounds through a multidisciplinary approach in Bolivia.: Part II.: Antimalarial activity of some plants used by Mosetene indians
The search for natural bioactive compounds through a multidisciplinary approach in Bolivia.: Part II.: Antimalarial activity of some plants used by Mosetene indians
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DOI：
10.1016/s0378-8741(99)00096-3
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发表时间：
2000-02-01
影响因子：
5.4
通讯作者：
Deharo, E
中科院分区：
文献类型：
--
作者：
Muñoz, V;Sauvain, M;Deharo, E
对居住在玻利维亚安第斯山麓的 Mosetene 民族收集的 46 个不同物种进行了抗疟特性筛选。在体外筛选了 33 种提取物对恶性疟原虫氯喹抗性菌株 (Indo) 的抗疟活性，并在体内评估了 47 种提取物对啮齿动物疟疾 P. vinckei petteri 279BY 的抗疟活性。 Mosetene 专门联合使用两种植物（Hymenachne donacifolia 和 Tesseria integrifolia）来对抗疟疾，但在 1000 mg/kg 浓度下，它们在体内没有表现出任何活性。体内活性最高的提取物是桃花心木树皮、金黄树皮和美洲三叶草树皮，但并非所有这些提取物都被 Mosetene 用于抗疟目的。以下提取物具有中等活性：雅卡拉树皮内皮和苦瓜地上部分（传统上均用作退热药）、长寿羽状地上部分（用于炎症过程）、小花月珠枝和叶、叶下珠（用作杀鱼剂）、Tynanthus schumannianus 果实（用于治疗腹泻）、Triumfetta semitrilobata （用作退热药，缓解肾脏和妇科疼痛），最后是茄果（用于治疗疥疮）。我们在此介绍本次筛选的结果，重点关注所选植物的体内抗疟活性。然后讨论了所选物种的体内抗疟活性及其传统 Mosetene 使用的关系。 (C) 2000 年由 Elsevier Science Ireland Ltd 出版。保留所有权利。
Forty-six different species collected in the Mosetene ethnia, dwelling in the Andean Piedmont of Bolivia, were screened for antimalarial properties. Thirty-three extracts were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine resistant strain (Indo), and forty-seven extracts were evaluated in vivo on the rodent malaria P. vinckei petteri 279BY. Only two plants are specifically used in combination by the Mosetene against malaria attack (Hymenachne donacifolia and Tesseria integrifolia), but they did not display any activity in vivo at 1000 mg/kg. The in vivo most active extracts were Swietenia macrophylla bark, Trema micrantha bark and Triplaris americana bark, not all of them were used for antimalarial purposes by the Mosetene. The following extracts were moderately active: Jacaratia digitata inner bark and Momordica charantia aerial part (both traditionally used as febrifuge), Kalanchoe pinnate aerial part (used in inflammatory processes), Lunania parviflora twigs and leaves, Phyllanthus acuminatus (used as piscicide), Tynanthus schumannianus fruit (used against diarrhoea), Triumfetta semitrilobata (used as febrifuge, to alleviate kidney and gynecological pain) and finally Solanum mammosum fruit (used against scabies). We present here the results of this screening, emphazing on the in vivo antimalarial activity of the selected plants. The antimalarial in vivo activity of the selected species, in relation with their traditional Mosetene use is then discussed. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.