BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke
复制标题
BaHoF5纳米探针作为高性能造影剂用于缺血性中风的多模态CT成像
DOI：
10.1016/j.biomaterials.2015.08.038
复制
发表时间：
2015-12-01
期刊：
影响因子：
14
通讯作者：
Yao, Zhenwei
中科院分区：
文献类型：
--
作者：
Wang, Jing;Ni, Dalong;Yao, Zhenwei
CT 血管造影 (CTA) 和 Cr 灌注 (CTP) 成像在急性缺血性中风的检查中发挥重要作用。然而，这些技术受到需要大量造影剂（CA）、高剂量的 X 射线辐射暴露以及临床使用的碘化 CA 的肾毒性的阻碍。为了解决这些问题，我们合成并验证了一类新型Cr CA，即聚乙二醇化BaHoF5纳米颗粒（NP），用于CFA和CTP成像，可以大大提高缺血性中风的诊断灵敏度和准确性。这些试剂比传统的碘化铬试剂具有独特的优势，包括所需剂量低得多、主要通过肝脏代谢以及在不同电压下更好的成像效率。一旦转化，这些聚乙二醇化的 BaHoF5 NP 可以取代基于碘的 CM，用于肾脏/心脏病患者的诊断对比增强成像，并提高总体诊断指数，且副作用可以忽略不计。 (C) 2015 Elsevier Ltd. 保留所有权利。
CT angiography (CTA) and Cr perfusion (CTP) imaging can play important roles in the workup of acute ischemic stroke. However, these techniques are hindered by the large amounts of contrast agents (CAs) required, high doses of X-ray radiation exposure, and nephrotoxicity of the clinical used iodinated CAs. To address these problems, we synthesized and validated a novel class of Cr CAs, PEGylated BaHoF5 nanoparticles (NPs), for CFA and CTP imaging, which can greatly enhance the diagnostic sensitivity and accuracy of ischemic stroke. These agents have unique advantages over conventional iodinated Cr agents, including much lower dosage required, major metabolism through liver and better imaging efficiency at different voltages. Once translated, these PEGylated BaHoF5 NPs can replace iodine-based CM for diagnostic contrast-enhanced imaging of patients with kidney/heart diseases and improve the overall diagnostic index with negligible side effects. (C) 2015 Elsevier Ltd. All rights reserved.