Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents
Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents
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DOI：
10.1016/s0040-4020(02)00411-8
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发表时间：
2002-05-27
期刊：
影响因子：
2.1
通讯作者：
Knochel, P
中科院分区：
文献类型：
--
作者：
Bonnet, V;Mongin, F;Knochel, P
芳基卤化镁（苯基氯化镁、异三甲苯基溴化镁、4-（甲氧基羰基）苯基氯化镁和4-氰基苯基氯化镁）与卤代吡啶之间的钯催化交叉偶联反应可以合成取代的吡啶。由于使用的条件非常温和（通常低于 0℃），该反应可以扩展到使用官能化的卤代吡啶、卤代喹啉和卤代二嗪。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
The palladium-catalyzed cross-coupling reactions between arylmagnesium halides (phenylmagnesium chloride, mesitylmagnesium bromide, 4-(methoxycarbonyl)phenylmagnesium chloride and 4-cyanophenylmagnesium chloride) and halopyridines allowed the synthesis of substituted pyridines. Owing to the remarkably mild conditions used (often below 0degreesC), the reaction could be extended to the use of functionalized halopyridines, haloquinolines and halodiazines. (C) 2002 Elsevier Science Ltd. All rights reserved.