Correlation of serum BNP and ET-1 levels with cardiac pump function and ventricular remodeling in patients with heart failure
Correlation of serum BNP and ET-1 levels with cardiac pump function and ventricular remodeling in patients with heart failure
复制标题
DOI：
10.14715/cmb/2020.66.3.19
复制
发表时间：
2020-01-01
影响因子：
1.6
通讯作者：
Li, Yi
中科院分区：
文献类型：
--
作者：
Qin, Limin;Liu, Xiaohong;Li, Yi
本研究旨在探讨心力衰竭患者血清脑钠肽（BNP）和内皮素-1 （ET-1）水平与心脏泵功能和心室重构的相关性。选取2016年3月至2018年11月我院收治的81例慢性心力衰竭患者为研究组，80例健康个体为对照组。采用免疫荧光法检测血清BNP， ELISA法检测血清ET-1，超声检测心泵功能及心室重构相关指标。并进行相关分析和预后因素分析。心衰患者血清中BNP和ET-1均高表达。研究组的心泵功能相关指标（左房射血分数（LAEF）、左房被动射血分数（LAPEF）、左房主动射血分数（LAAEF））均显著低于对照组(P
This study aimed to explore the correlation of serum brain natriuretic peptide (BNP) and endothelin-1 (ET-1) levels with cardiac pump function and ventricular remodeling in patients with heart failure. Eighty-one patients with chronic heart failure admitted to our hospital from March 2016 to November 2018 were enrolled as the study group, and 80 healthy individuals as the control group. Immunofluorescence was used for the detection of serum BNP, ELISA for serum ET-1, and ultrasound for related indexes of cardiac pump function and ventricular remodeling. Moreover, correlation analysis and prognostic factors analysis were carried out. Both BNP and ET-1 were highly expressed in the serum of patients with heart failure. Cardiac pump function related indexes (left atrial ejection fraction (LAEF), left atrial passive ejection fraction (LAPEF), and left atrial active ejection fraction (LAAEF)) in the study group were significantly lower than those in the control group (P