Professional Fighters Brain Health Study: Rationale and Methods
Professional Fighters Brain Health Study: Rationale and Methods
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DOI：
10.1093/aje/kws456
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发表时间：
2013-07-15
影响因子：
5
通讯作者：
Modic, Michael
中科院分区：
文献类型：
--
作者：
Bernick, Charles;Banks, Sarah;Modic, Michael
重复性头部创伤是阿尔茨海默病的危险因素，也是慢性创伤性脑病的主要原因。然而，人们对慢性创伤性脑病的自然病史和危险因素以及早期发现和干预的方法知之甚少。职业拳手大脑健康研究是一项纵向研究，研究对象包括现役职业拳手（拳击手和综合格斗艺术家）、退休职业拳手，以及年龄和教育水平相匹配的对照组。职业拳手脑健康研究的主要目标是确定头部创伤暴露测量与其他潜在修饰因素之间的关系，以及随着时间的推移，脑成像、神经和行为功能的变化。这项研究将持续5年以上，我们预计将招募400多名拳击手和综合格斗家。参与者将接受年度评估，包括3特斯拉磁共振成像扫描、计算机认知评估、语音分析、情绪和冲动调查，以及用于基因分型和探索性生物标志物研究的血液采样。将开发和验证统计模型，以预测大脑结构和功能的早期和渐进变化。一种综合格斗暴露指数被开发出来，作为累积创伤暴露的综合衡量标准，有望作为脑容量和认知功能的预测指标。
Repetitive head trauma is a risk factor for Alzheimer's disease and is the primary cause of chronic traumatic encephalopathy. However, little is known about the natural history of, and risk factors for, chronic traumatic encephalopathy or about means of early detection and intervention. The Professional Fighters Brain Health Study is a longitudinal study of active professional fighters (boxers and mixed martial artists), retired professional fighters, and controls matched for age and level of education. The main objective of the Professional Fighters Brain Health Study is to determine the relationships between measures of head trauma exposure and other potential modifiers and changes in brain imaging and neurological and behavioral function over time. The study is designed to extend over 5 years, and we anticipate enrollment of more than 400 boxers and mixed martial artists. Participants will undergo annual evaluations that include 3-tesla magnetic resonance imaging scanning, computerized cognitive assessments, speech analysis, surveys of mood and impulsivity, and blood sampling for genotyping and exploratory biomarker studies. Statistical models will be developed and validated to predict early and progressive changes in brain structure and function. A composite fight exposure index, developed as a summary measure of cumulative traumatic exposure, shows promise as a predictor of brain volumes and cognitive function.