An efficient method for removal of ruthenium byproducts from olefin metathesis reactions
An efficient method for removal of ruthenium byproducts from olefin metathesis reactions
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DOI：
10.1021/ol027423l
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发表时间：
2003-02-20
期刊：
影响因子：
5.2
通讯作者：
Kim, BM
中科院分区：
文献类型：
--
作者：
Cho, JH;Kim, BM
依次用硅胶、活性炭（相对于粗产物为50当量重量）和硅胶柱色谱法处理闭环复分解反应产物，有效地从反应混合物中除去了深棕色钌副产物。在该处理之后，可以获得无色化合物，钌水平为0.06-0.53 μ g/5 mg产物。
[GRAPHICS]Sequential treatment of the ring-closing metathesis reaction products with silica gel, activated carbon (50 equiv wt relative to the crude products), and column chromatography on silica gel efficiently removed dark brown ruthenium byproducts from the reaction mixture. After this treatment, colorless compounds could be obtained with a ruthenium level of 0.06-0.53 mug per 5 mg of product.