Plasticity compartments in basal dendrites of neocortical pyramidal neurons
Plasticity compartments in basal dendrites of neocortical pyramidal neurons
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DOI：
10.1523/jneurosci.3502-06.2006
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发表时间：
2006-12-06
影响因子：
5.3
通讯作者：
Schiller, Jackie
中科院分区：
文献类型：
--
作者：
Gordon, Urit;Polsky, Alon;Schiller, Jackie
突触可塑性规则广泛地决定了皮层网络如何发展和存储信息。使用共聚焦成像和双站点焦点突触刺激，我们表明，基底树突，其中接收大部分的突触支配新皮层锥体神经元，包含两个隔间相对于可塑性规则。当与神经元的全局活动配对时，支配近端基底树的突触容易被修改。相反，神经支配远端基底树的突触未能改变响应全球阈上活动或局部树突棘波。这些突触可以在不寻常的条件下经历长时程增强，当局部NMDA尖峰，引起大的钙瞬变，与“门控分子”，BDNF配对。此外，这些突触使用一个新的时间可塑性规则，这是一个数量级长于尖峰时间依赖的可塑性，更喜欢反转突触前/突触后激活顺序。基底树突的可塑性分区扩展了网络可塑性规则，并可能支持不同的学习和发育功能。
Synaptic plasticity rules widely determine how cortical networks develop and store information. Using confocal imaging and dual site focal synaptic stimulation, we show that basal dendrites, which receive the majority of synapses innervating neocortical pyramidal neurons, contain two compartments with respect to plasticity rules. Synapses innervating the proximal basal tree are easily modified when paired with the global activity of the neuron. In contrast, synapses innervating the distal basal tree fail to change in response to global suprathreshold activity or local dendritic spikes. These synapses can undergo long-term potentiation under unusual conditions when local NMDA spikes, which evoke large calcium transients, are paired with a "gating molecule," BDNF. Moreover, these synapses use a new temporal plasticity rule, which is an order of magnitude longer than spike timing dependent plasticity and prefers reversed presynaptic/postsynaptic activation order. The newly described plasticity compartmentalization of basal dendrites expands the networks plasticity rules and may support different learning and developmental functions.