Protective immunity to influenza: lessons from the virus for successful vaccine design
Protective immunity to influenza: lessons from the virus for successful vaccine design
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DOI：
10.1586/erv.09.35
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发表时间：
2009-06-01
影响因子：
6.2
通讯作者：
Castrucci, Maria R.
中科院分区：
文献类型：
--
作者：
Garulli, Bruno;Castrucci, Maria R.
开发有效的流感疫苗需要能够防止多种流感病毒株的感染。特别是，粘膜和T细胞介导的免疫可能为预防流行性或潜在的大流行性流感提供更具交叉反应性的疫苗方法。因此，有必要更全面地了解感染活病毒后宿主中发生的分子事件，特别是更好地评估参与发展保护性免疫应答的不同信号通路的作用。本文介绍了体内造血细胞中caspase-1炎性小体的激活是建立针对流感病毒感染的Th 1、细胞毒性T淋巴细胞和伊加反应所必需的概念。
The development of an effective influenza vaccine would require the ability to protect against infection with multiple influenza viral strains. In particular, mucosal and T-cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of epidemic or potentially pandemic influenza. Thus, it is imperative to more fully understand the molecular events that occur in the host upon infection with a live virus and, in particular, to better evaluate the role of the distinct signaling pathways involved in developing protective immune responses. The paper under evaluation here introduces the notion that activation of caspase-1 inflammasomes in the hematopoietic cells in vivo are required for the establishment of Th1, cytotoxic T-lymphocyte and IgA responses to influenza virus infection.