Left Ventricular T1 Mapping during Chemotherapy-Radiation Therapy: Serial Assessment of Participants with Esophageal Cancer
Left Ventricular T1 Mapping during Chemotherapy-Radiation Therapy: Serial Assessment of Participants with Esophageal Cancer
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DOI：
10.1148/radiol.2018172076
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发表时间：
2018-11-01
期刊：
影响因子：
19.7
通讯作者：
Takase, Kei
中科院分区：
文献类型：
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作者：
Takagi, Hidenobu;Ota, Hideki;Takase, Kei
目的：为了评估左心室功能和组织成分的变化，通过使用MRI化疗后，放射治疗的参与者与esophageal cancer.Materials和Methods：在2013年1月和2015年4月之间，这项前瞻性研究招募了24名参与者（42%女性;平均年龄，63岁;范围，49-73岁）计划化疗-放射治疗。在化疗-放疗前、0.5年和1.5年后进行3.0-T MRI检查。测量基底隔（作为照射区域）和顶侧壁（作为非照射区域）的心肌天然T1、造影后T1和细胞外容积。随访期间采用Friedman或Cochran Q检验比较左心室功能、晚期钆增强的发生率以及T1和细胞外容积值，然后进行Dunn检验。在14名随访1.5年的参与者中，与基线相比，0.5年时间隔中的天然T1和细胞外容积升高（1183 msec +/- 46 [标准差] vs 1257 msec +/- 35; 26% +/- 3 vs 32% +/- 3;两者校正后P <0.01），但侧壁中没有。与基线相比，1.5年时左心室每搏输出量指数和晚期钆增强发生变化（41 mL/m2 +/- 11 vs 36 mL/m2 +/- 9; P = 0.046; 7% [14例中的1例] vs 78% [14例中的11例]; P <0.01）。结论：自然T1和细胞外容积可检测放化疗后0.5年心肌的早期变化，而左室每搏输出量指数和晚期钆增强在1.5年时显示异常。(c)RSNA，2018
Purpose: To assess changes in left ventricular function and tissue composition by using MRI after chemotherapy-radiation therapy in participants with esophageal cancer.Materials and Methods: Between January 2013 and April 2015, this prospective study enrolled 24 participants (42% women; mean age, 63 years; range, 49-73 years) scheduled for chemotherapy-radiation therapy. 3.0-T MRI examinations were performed before, at 0.5 year, and at 1.5 years after chemotherapy-radiation therapy. Myocardial native T1, postcontrast T1, and extracellular volume were measured in basal septum (as irradiated areas) and apical lateral wall (as nonirradiated areas). Left ventricular function, prevalence of late gadolinium enhancement, and T1 and extracellular volume values were compared over the follow-up period by using Friedman or Cochran Q tests, followed by Dunn test.Results: In 14 participants who were followed up for 1.5 years, native T1 and extracellular volume in the septum were elevated at 0.5 year compared with baseline (1183 msec +/- 46 [standard deviation] vs 1257 msec +/- 35; 26% +/- 3 vs 32% +/- 3; adjusted P < .01 for both), but not in the lateral wall. Left ventricular stroke volume index and late gadolinium enhancement changed at 1.5 years compared with baseline (41 mL/m(2) +/- 11 vs 36 mL/m(2) +/- 9; P = .046; 7% [one of 14] vs 78% [11 of 14]; P < .01). Other measures of left ventricular function did not change during the follow-up period (P > .10 for all).Conclusion: Native T1 and extracellular volume could detect early changes in myocardium at 0.5 year after chemotherapy-radiation therapy, whereas left ventricular stroke volume index and late gadolinium enhancement showed abnormality at 1.5 years. (c) RSNA, 2018