RNA templating the epigenome Long noncoding RNAs as molecular scaffolds
RNA templating the epigenome Long noncoding RNAs as molecular scaffolds
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DOI：
10.4161/epi.6.5.15221
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发表时间：
2011-05-01
期刊：
影响因子：
3.7
通讯作者：
Chang, Howard Y.
中科院分区：
文献类型：
--
作者：
Spitale, Robert C.;Tsai, Miao-Chih;Chang, Howard Y.
细胞通路必须协同，控制和组织管理稳态。为了在拥挤的细胞环境中实现高选择性，细胞利用支架复合物，其作用是使分子接近，从而控制和增强分子间相互作用和信号传导事件。到目前为止，支架已被证明是由蛋白质单位组成;然而，最近的证据支持的想法，非编码RNA也可能发挥类似的作用。在这篇观点文章中，我们讨论了ncRNA支架的最新数据，特别关注ncRNA HOTAIR。利用我们目前对信号网络的了解，我们讨论了RNA在书写和调节组蛋白修饰中可能发挥的作用以及正确基因表达所需的信息。此外，我们推测ncRNA可能作为分子支架发挥的其他尚未发现的作用。
Cellular pathways must be synergized, controlled and organized to manage homeostasis. To achieve high selectivity within the crowded cellular milieu the cell utilizes scaffolding complexes whose role is to bring molecules in proximity thereby controlling and enhancing intermolecular interactions and signaling events. To date, scaffolds have been shown to be composed of proteinaceous units; however, recent evidence has supported the idea that non-coding RNAs may also play a similar role. In this point of view article we discuss recent data on ncRNA scaffolds, with particular focus on ncRNA HOTAIR. Using our current knowledge of signaling networks we discuss the role that RNA may play in writing and regulating histone modifications and the information needed for correct gene expression. Further, we speculate on additional, yet undiscovered roles that ncRNAs may be playing as molecular scaffolds.