Cilia and ciliopathies:: From Chlamydomonas and beyond
Cilia and ciliopathies:: From Chlamydomonas and beyond
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纤毛和纤毛病：来自衣藻及其他疾病
DOI：
10.1007/s11427-008-0071-3
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发表时间：
2008-06-01
期刊：
影响因子：
--
通讯作者：
Pan JunMin
中科院分区：
文献类型：
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作者：
Pan JunMin
游动纤毛/鞭毛的生物学功能早已为人们所认识。不活动的初级纤毛曾被认为是一种退化细胞器，但最近发现它在哺乳动物的生理和发育中扮演着意想不到的角色。纤毛缺陷对人类健康有着深远的影响。与纤毛相关的疾病，统称为纤毛疾病，包括男性不育症、原发纤毛运动障碍、肾囊肿形成、失明、多指、肥胖、高血压，甚至智力低下。我们目前对纤毛和纤毛病的理解是由基础研究推动的，这些研究使用了各种模式生物，包括衣藻，一种单细胞绿藻。本文对纤毛的细胞生物学进行了概述，并对纤毛相关疾病进行了综述。
The biological function of motile cilia/flagella has long been recognized. The non-motile primary cilium, once regarded as a vestigial organelle, however, has been found recently to play unexpected roles in mammalian physiology and development. Defects in cilia have profound impact on human health. Diseases related to cilia, collectively called ciliopathies include male infertility, primary cilia dyskinesia, renal cyst formation, blindness, polydactyly, obesity, hypertension, and even mental retardation. Our current understanding of cilia and ciliopathies has been fueled by basic research employing various model organisms including Chlamydomonas, a unicellular green alga. This review article provides a general introduction to the cell biology of cilia and an overview of various cilia-related diseases.