DIFFERENTIAL ADHESION OF TUMOR-CELLS TO CAPILLARY ENDOTHELIAL-CELLS INVITRO
DIFFERENTIAL ADHESION OF TUMOR-CELLS TO CAPILLARY ENDOTHELIAL-CELLS INVITRO
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DOI：
10.1073/pnas.81.18.5739
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
AUERBACH, R
中科院分区：
文献类型：
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作者：
ALBY, L;AUERBACH, R
进行粘附研究以确定神经胶质瘤细胞和卵巢来源的畸胎瘤细胞粘附于从小鼠脑毛细血管（指定为MBE细胞系）或小鼠卵巢（指定为MOE细胞系）获得的内皮细胞的相对能力。畸胎瘤细胞显示出对 MOE 细胞的优先粘附，而神经胶质瘤细胞显示出对 MBE 细胞系的优先粘附。神经胶质瘤和畸胎瘤细胞同样粘附于 L929 和 3T3 成纤维细胞。体内具有卵巢寻找特性的睾丸畸胎瘤也优先粘附于 MOE 细胞，而神经胶质瘤细胞、内皮瘤和膀胱肿瘤细胞系也偏好 MBE 细胞。有趣的是，内皮瘤表现出对 3T3 细胞的明显优先粘附，从而将其与神经胶质瘤区分开来。不同来源的毛细血管内皮细胞并不相似，这些细胞表面表达的差异可以通过肿瘤细胞来区分。
Adhesion studies were carried out to determine the relative ability of glioma cells and ovary-derived teratoma cells to adhere to endothelial cells obtained from mouse brain capillaries (designated MBE cell line) or mouse ovaries (designated MOE cell line). The teratoma cells showed preferential adhesion to MOE cells, whereas the glioma cells showed preferential adhesion to the MBE cell line. The glioma and teratoma cells adhered equally to L929 and 3T3 fibroblasts. A testicular teratoma with ovary-seeking properties in vivo also adhered preferentially to MOE cells, while the preference for MBE cells was shared by glioma cells with an endothelioma and a bladder tumor line. The endothelioma, interestingly, showed a marked preferential adhesion to 3T3 cells, thus distinguishing it from the glioma. Capillary endothelial cells derived from different sources are not alike, and differences expressed at the cell surface of these cells can be distinguished by tumor cells.