APOPTOSIS, LYMPHOCYTOTOXICITY AND THE CONTAINMENT OF VIRAL-INFECTIONS
APOPTOSIS, LYMPHOCYTOTOXICITY AND THE CONTAINMENT OF VIRAL-INFECTIONS
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DOI：
10.1016/0306-9877(85)90107-0
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发表时间：
1985-01-01
影响因子：
4.7
通讯作者：
KERR, JFR
中科院分区：
文献类型：
--
作者：
CLOUSTON, WM;KERR, JFR
人们普遍认为细胞免疫在限制某些原发性病毒感染方面发挥着重要作用。形态学研究表明，T 细胞、K 细胞和 NK 细胞诱导的细胞死亡采取细胞凋亡的形式，而不是经典的坏死。在感染性病毒组装之前通过这些方法中的任何一种杀死病毒感染的细胞将明显遏制感染。我们的假设是，细胞凋亡仅参与淋巴细胞毒性可能在防止病毒传播方面具有额外的优势。首先，细胞凋亡的一个非常早期的事件是内源性非溶酶体核酸内切酶的激活，这可能会破坏病毒。其次，细胞凋亡导致膜结合细胞碎片的形成，这些碎片被完整地吞噬并在相邻细胞的溶酶体内消化。相反，坏死通常与细胞膜破裂和细胞内容物释放相关。未萌芽病毒的诱导有助于感染的传播。
It is generally agreed that cellular immunity plays an important role in limiting certain primary viral infections. Morphological studies indicate that cell death induced by T cells, K cells and NK cells takes the form of apoptosis, not classical necrosis. Killing of a virus-infected cell by either of these means prior to the assembly of infectious virus would clearly contain the infection. Our hypothesis is that the exclusive involvement of apoptosis in lymphocytotoxicity may have additional advantages in preventing virus dissemination. Firstly, a very early event in apoptosis is activation of endogenous, non-lysosomal endonuclease, and this might destroy virus. Secondly, apoptosis results in the formation of membrane-bound cell fragments, which are phagocytosed intact and digested within the lysosomes of adjacent cells. In contrast, necrosis is characteristically associated with rupture of the cell membrane and release of cellular contents; its induction by non-budding viruses aids in spread of the infection.