Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma
Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma
复制标题
HMG-box家族的鉴定确立了SOX6在胶质母细胞瘤恶性进展中的意义
DOI：
10.18632/aging.103127
复制
发表时间：
2020-05-15
期刊：
影响因子：
5.2
通讯作者：
Lv, Kun
中科院分区：
文献类型：
--
作者：
Jiang, Lan;Yang, Hui;Lv, Kun
多形性胶质母细胞瘤（GBM）是恶性程度最高的原发性脑神经上皮肿瘤，确诊后平均生存时间为15个月。本研究旨在探讨人类高迁移率族蛋白盒（HMG-box）转录因子家族/ HOX、TOX、FOX、HMG和SOX基因家族的全基因组和全转录组分析及其与GBM的关系。根据TCGA-GBM图谱分析，本研究发现差异表达的HOX，FOX，HMG和SOX基因家族（62 DEmRNA）。我们还分析了GBM中DEmRNA（HMG盒相关基因）共表达的8种DElncRNA，并构建了ceRNA网络分析。我们在GBM和正常组织中构建了50对DElncRNA-DEmiRNA-DEmRNA（HMG盒相关基因）对。然后，危险基因SOX 6和SOX 21的表达与GBM中的免疫浸润水平相关。SOX 6与MAPT、GSK 3B、FYN和DPYSL 4也有很强的相关性，提示它们可能是GBM的功能成员。
Glioblastoma multiforme (GBM) is the most malignant neuroepithelial primary brain tumor and its mean survival time is 15 months after diagnosis. This study undertook to investigate the genome-wide and transcriptome-wide analyses of human high mobility group box (HMG-box) TF (transcript factor) families / HOX, TOX, FOX, HMG and SOX gene families, and their relationships to GBM. According to the TCGA-GBM profile analysis, differentially expressed HOX, FOX, HMG and SOX gene families (62 DEmRNA) were found in this study. We also analyzed DEmRNA (HMG-box related genes) co-expressed eight DElncRNA in GBM, and constructed a ceRNA network analysis as well. We constructed 50 DElncRNA-DEmiRNA-DEmRNA (HMG-box related genes) pairs between GBM and normal tissues. Then, risk genes SOX6 and SOX21 expression were correlated with immune infiltration levels in GBM. SOX6 also had a strong association with MAPT, GSK3B, FYN and DPYSL4, suggesting that they might be functional members in GBM.