PERSONALITY CHANGES IN ALZHEIMERS-DISEASE
PERSONALITY CHANGES IN ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1992.00530290070014
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发表时间：
1992-05-01
影响因子：
--
通讯作者：
WHITEHOUSE, PJ
中科院分区：
文献类型：
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作者：
CHATTERJEE, A;STRAUSS, ME;WHITEHOUSE, PJ
阿尔茨海默氏症患者的性格如何变化还不清楚。已经假设了病前人格的加重、人格特质的系统性变化以及影响患者亚型的特定人格变化。为了调查这些替代品中的哪一种发生在阿尔茨海默氏病中，照顾者被给予了一个全面的人格调查表，该调查表标准化供被调查者使用。照顾者观察到更多的神经质，不外向，不认真的行为。在较小程度上，阿尔茨海默病患者被报告为变得不那么令人愉快和不那么开放。神经质、外向性、宜人性和开放性报告的变化表明所有患者的系统性变化一致。据报道，有抑郁特征的患者更神经质;那些有偏执妄想症的患者更有敌意。发病前的人格特征可能会导致阿尔茨海默病患者随后出现精神症状。
How personality changes in Alzheimer's disease is not well understood. Accentuations of premorbid personality, systematic shifts in personality traits, and specific personality changes affecting subtypes of patients have been postulated. To investigate which of these alternatives occurs in Alzheimer's disease, caregivers were given a comprehensive personality inventory standardized for use by informants. Caregivers observed more neurotic, less extroverted, and less conscientious behavior. To a smaller extent, patients with Alzheimer's disease were reported as becoming less agreeable and less open. The changes in reports of neuroticism, extroversion, agreeableness, and openness suggested consistent systematic shifts across all patients. Patients with depressive features were reported to have been more neurotic; those with paranoid delusions were reported as having been more hostile. Premorbid personality traits may predispose to subsequent psychiatric symptoms in Alzheimer's disease.