The Relationship Between Midlife and Late Life Alcohol Consumption, APOE e4 and the Decline in Learning and Memory Among Older Adults
The Relationship Between Midlife and Late Life Alcohol Consumption, APOE e4 and the Decline in Learning and Memory Among Older Adults
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DOI：
10.1093/alcalc/agt144
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发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Fardo, David W.
中科院分区：
文献类型：
--
作者：
Downer, Brian;Zanjani, Faika;Fardo, David W.
目的：该研究的目的是确定学习和记忆的轨迹是否根据中年或晚年饮酒状态与一个或多个APOE e4等位基因的存在之间的交互作用而改变。方法：这是对从弗雷明翰心脏研究后代队列成员收集的认知、遗传和酒精消费数据的二次分析。结果：在APOE e4携带者中，晚年轻度和中度饮酒与学习和记忆能力下降程度较大相关，而在非APOE e4携带者中，轻度和中度饮酒与学习和记忆能力增强相关。中年饮酒状况与apoe e4在学习记忆轨迹上没有显著的交互作用。结论：对于非载脂蛋白E e4等位基因携带者来说，晚年少量或适度饮酒可以防止学习和记忆能力下降，但对于携带一个或多个载脂蛋白E e4等位基因的老年人来说，这并不是一种保护作用。
Aims: The aim of the study was to determine whether the trajectory of learning and memory is modified according to an interaction between midlife or late life alcohol consumption status and the presence of one or more APOE e4 alleles. Methods: This was a secondary analysis of cognitive, genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort. Results: Light and moderate alcohol consumption during late life was associated with greater decline in learning and memory among APOE e4 carriers, whereas light and moderate alcohol consumption was associated with an increase in learning and memory among non-APOE e4 carriers. There was not a significant interaction between midlife alcohol consumption status and APOE e4 on the trajectory of learning and memory. Conclusion: Light to moderate alcohol consumption during late life may protect against a decline in learning and memory for non-APOE e4 allele carriers, but not for older adults who carry one or more APOE e4 alleles.