Advances in extracellular vesicle functionalization strategies for tissue regeneration
Advances in extracellular vesicle functionalization strategies for tissue regeneration
复制标题
DOI：
10.1016/j.bioactmat.2022.07.022
复制
发表时间：
2022
影响因子：
18.9
通讯作者：
Hongxing Shen
中科院分区：
文献类型：
--
作者：
Dandan Zheng;Huitong Ruan;Wei Chen;Yuhui Zhang;Wenguo Cui;Hao Chen;Hongxing Shen
Extracellular vesicles (EVs) are nano-scale vesicles derived by cell secretion with unique advantages such as promoting cell proliferation, anti-inflammation, promoting blood vessels and regulating cell differentiation, which benefit their wide applications in regenerative medicine. However, the in vivo therapeutic effect of EVs still greatly restricted by several obstacles, including the off-targetability, rapid blood clearance, and undesired release. To address these issues, biomedical engineering techniques are vastly explored. This review summarizes different strategies to enhance EV functions from the perspective of drug loading, modification, and combination of biomaterials, and emphatically introduces the latest developments of functionalized EV-loaded biomaterials in different diseases, including cardio-vascular system diseases, osteochondral disorders, wound healing, nerve injuries. Challenges and future directions of EVs are also discussed. • Extracellular vesicles (EVs) offer a safe and efficient solution for degenerative diseases. • Advantages and limitations of Drug-loading and modifications of EVs. • Biomaterial-assisted EV delivery to overcome its physical shortcomings. • With the help of EV-engineering, the road between EVs isolation and applications in regeneration medicine has been paved.
