Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans
Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans
复制标题
DOI：
10.1093/ajcn/67.2.332
复制
发表时间：
1998-02-01
影响因子：
7.1
通讯作者：
Shultz, TD
中科院分区：
文献类型：
--
作者：
Herbel, BK;McGuire, MK;Shultz, TD
共轭亚油酸（CLA）是具有共轭双键的亚油酸（LA）的位置异构体和几何异构体的混合物。 CLA 具有抗癌特性，已在人体组织、乳制品、肉类和某些植物油中发现。多种动物产品都是 CLA 的良好来源，但植物油的含量要少得多。然而，植物油是 LA 的丰富来源，LA 可能被人体肠道微生物异构化为 CLA。为了研究三酰甘油酯化 LA 消耗量对总脂质中酯化 CLA 血浆浓度的影响，对 6 名男性和 6 名女性进行了饮食干预（6 周）。在干预期间，受试者的日常饮食中添加了含有 21 克红花油的沙拉酱，每天提供 16 克 LA。在最初以及饮食干预期间和饮食干预后期间获得三天饮食记录和空腹血液。尽管膳食干预期间 LA 摄入量显着增加，但血浆 CLA 浓度并未受到影响。在饮食中添加红花油后，血浆总胆固醇和低密度脂蛋白胆固醇浓度显着降低。总之，食用红花油中的三酰甘油酯化 LA 不会增加总脂质中酯化 CLA 的血浆浓度。
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid (LA) with conjugated double bonds. CLA has anticarcinogenic properties and has been identified in human tissues, dairy products, meats, and certain vegetable oils. A variety of animal products are good sources of CLA, but plant oils contain much less. However, plant oils are a rich source of LA, which may be isomerized to CLA by intestinal microorganisms in humans. To investigate the effect of triacylglycerol-esterified LA consumption on plasma concentrations of esterified CLA in total lipids, a dietary intervention (6 wk) was conducted with six men and six women. During the intervention period a salad dressing containing 21 g safflower oil providing 16 g LA/d was added to the subjects' daily diets. Three-day diet records and fasting blood were obtained initially and during dietary and postdietary intervention periods. Although LA intake increased significantly during the dietary intervention, plasma CLA concentrations were not affected. Plasma total cholesterol and LDL-cholesterol concentrations were significantly lower after addition of safflower oil to the diet. In summary, consumption of triacylglycerol-esterified LA in safflower oil did not increase plasma concentrations of esterified CLA in total lipids.