1‐Benzyl‐1,2,3,4‐Tetrahydroisoquinoline as a Parkinsonism‐Inducing Agent: A Novel Endogenous Amine in Mouse Brain and Parkinsonian CSF
1‐Benzyl‐1,2,3,4‐Tetrahydroisoquinoline as a Parkinsonism‐Inducing Agent: A Novel Endogenous Amine in Mouse Brain and Parkinsonian CSF
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1-苄基-1,2,3,4-四氢异喹啉作为帕金森病诱导剂：小鼠脑和帕金森病脑脊液中的一种新型内源性胺
DOI：
10.1046/j.1471-4159.1995.65062633.x
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发表时间：
1995
影响因子：
4.7
通讯作者：
M. Hirobe
中科院分区：
文献类型：
--
作者：
Y. Kotake;Y. Tasaki;Y. Makino;S. Ohta;M. Hirobe
摘要：采用气相色谱选择离子监测法检测到1-苄基-1，2，3，4-四氢异喹啉（1BnTIQ）在小鼠脑和帕金森病CSF中作为一种新的内源性胺。与患有其他神经系统疾病的对照组相比，一些帕金森病患者的CSF中的1BnTIQ水平非常高，平均值高3倍（帕金森病患者：CSF的1.17 ± 0.35 ng/ml，n = 18;与对照组：CSF的0.40 ± 0.10 ng/ml，n = 11;平均值± SEM，无显著差异）。使用杆试验（一种用于评价与帕金森病相关的行为异常的毒理学检查）来检查1BnTIQ在小鼠中的药理学作用。重复给予1BnTIQ诱导行为异常，1-甲基-1，2，3，4-四氢异喹啉预处理可以预防。提示1BnTIQ可能与原发性帕金森病有关。
Abstract: 1‐Benzyl‐1,2,3,4‐tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography‐selected ion‐monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological diseases, the mean value being three times higher (parkinsonians: 1.17 ± 0.35 ng/ml of CSF, n = 18; vs. controls: 0.40 ± 0.10 ng/ml of CSF, n = 11; mean ± SEM, not significantly different). The pole test, a toxicological examination to evaluate behavior abnormalities related to Parkinson's disease, was used to examine the pharmacological effect of 1BnTIQ in mice. Repeated administration of 1BnTIQ induced behavior abnormalities, which pretreatment with 1‐methyl‐1,2,3,4‐tetrahydroisoquinoline could prevent. We suggest that 1BnTIQ may be related to the idiopathic Parkinson's disease.