Application of bacteria and fungi as biocatalysts for the preparation of optically active hydroxyphosphonates
Application of bacteria and fungi as biocatalysts for the preparation of optically active hydroxyphosphonates
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DOI：
10.1016/j.molcatb.2003.12.013
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发表时间：
2004-06-21
影响因子：
--
通讯作者：
Lejczak, B
中科院分区：
文献类型：
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作者：
Kafarski, P;Lejczak, B
综述了近年来全细胞生物催化剂在光学活性羟基烷膦酸酯合成中的应用。迄今为止，有三种常用的方法，即使用脂解有机体对酰氧基烷烃膦酸酯的对映选择性水解或羟基烷烃膦酸酯的对映选择性酰化，使用面包酵母和其它真菌对酮基膦酸酯的生物还原，以及使用细菌和真菌对取代的1，2-环氧乙烷膦酸酯的水解环氧乙烷开环。(C)2004 Elsevier B. V.保留所有权利。
Review on the use of whole-cell biocatalysts for the preparation of optically active hydroxyalkanephosphonates is presented. There are three general processes applied so far, namely the use of lipolytic organisms either for enantio selective hydrolysis of acyloxyalkanephosphonates or enantioselective acylation of hydroxyalkanephosphonates, the use of baker's yeast and other fungi for bioreduction of ketophosphonates and the use of bacteria and fungi for hydrolytic oxirane ring opening in substituted 1,2-epoxyethanephosphonates. (C) 2004 Elsevier B.V. All rights reserved.