Disorganized Amygdala Networks in Conduct-Disordered Juvenile Offenders With Callous-Unemotional Traits
Disorganized Amygdala Networks in Conduct-Disordered Juvenile Offenders With Callous-Unemotional Traits
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DOI：
10.1016/j.biopsych.2016.05.017
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发表时间：
2017-08-15
影响因子：
10.6
通讯作者：
Colins, Olivier F.
中科院分区：
文献类型：
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作者：
Aghajani, Moji;Klapwijk, Eduard T.;Colins, Olivier F.
背景：精神变态的发展轨迹似乎开始于生命的早期，包括在品行障碍(CD)青少年中存在冷酷无情(CU)的特征(例如，缺乏情绪反应、冷酷无情)。尽管在反社会人群的CU病理生理学中发现了杏仁核功能的分区特异性异常，但对CU特征的系统水平研究通常将杏仁核作为一个单一的结构来检查。因此，目前还不知道杏仁核次区域网络功能如何在严重反社会人群中导致冷漠无情。方法：我们通过独特地研究杏仁基底外侧核(BLA)和中央内侧杏仁核(CMA)网络在三组匹配青少年中的内在功能连接来解决这一重要问题：有CU特征的CD罪犯(CD/CU+；n=25)，没有CU特征的CD罪犯(CD/CU-；n=25)，以及健康对照受试者(n=24)。此外，我们还检查了杏仁核次区域连接性是否与杏仁复合体的体积和形状的改变相一致。结果：相对于CD/CU-和健康对照组青年，CD/CU+青年表现出异常的BLA连接性增加，该簇包括前扣带回和内侧前额叶皮质的背侧和腹侧部分，以及后扣带回、感觉联合和纹状体区域。相反，与CD/CU-和健康对照组相比，CD/CU+青少年与腹内侧部/眶前区的CMA连接性减弱。关键是，这些连接性变化与BLA和CMA亚区局部萎缩(没有统计相关性)相一致，并与更严重的CU症状相关。结论：这些发现为干扰注意-情绪相互作用的可能机制提供了独特的见解，这种机制可能会使Cd/Cu+青少年的突显加工和联想学习发生偏差。
BACKGROUND: The developmental trajectory of psychopathy seemingly begins early in life and includes the presence of callous-unemotional (CU) traits (e.g., deficient emotional reactivity, callousness) in conduct-disordered (CD) youth. Though subregion-specific anomalies in amygdala function have been suggested in CU pathophysiology among antisocial populations, system-level studies of CU traits have typically examined the amygdala as a unitary structure. Hence, nothing is yet known of how amygdala subregional network function may contribute to callous-unemotionality in severely antisocial people.METHODS: We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral amygdala (BLA) and centromedial amygdala (CMA) networks across three matched groups of juveniles: CD offenders with CU traits (CD/CU+; n = 25), CD offenders without CU traits (CD/CU-; n = 25), and healthy control subjects (n = 24). We additionally examined whether perturbed amygdala subregional connectivity coincides with altered volume and shape of the amygdaloid complex.RESULTS: Relative to CD/CU- and healthy control youths, CD/CU+ youths showed abnormally increased BLA connectivity with a cluster that included both dorsal and ventral portions of the anterior cingulate and medial prefrontal cortices, along with posterior cingulate, sensory associative, and striatal regions. In contrast, compared with CD/CU- and healthy control youths, CD/CU+ youths showed diminished CMA connectivity with ventromedial/orbitofrontal regions. Critically, these connectivity changes coincided with local hypotrophy of BLA and CMA subregions (without being statistically correlated) and were associated to more severe CU symptoms.CONCLUSIONS: These findings provide unique insights into a putative mechanism for perturbed attention-emotion interactions, which could bias salience processing and associative learning in youth with CD/CU+.