Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer
Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer
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DOI：
10.1038/bjc.1997.459
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发表时间：
1997-09-01
影响因子：
8.8
通讯作者：
Mitelman, F
中科院分区：
文献类型：
--
作者：
Bardi, G;Parada, LA;Mitelman, F
对7例结直肠癌患者的30个肿瘤病灶进行了短期培养和细胞遗传学分析：16个非腺瘤性息肉，6个腺瘤，7个癌，包括1个息肉，1个淋巴结转移。在20个样本中发现克隆性染色体畸变，100%的癌，100%的腺瘤和37.5%的非腺瘤性息肉，即所有10个具有正常核型的病变组织学诊断为增生性息肉。虽然腺瘤和癌有一些共同的核型特征，但癌中发现了der（8;17）（q10;q10）和-14两种染色体畸变，而腺瘤中未发现，这表明它们可能与大肠粘膜癌的发生有关。同一患者的恶性和良性肿瘤之间以及同一病例的非恶性息肉之间的核型相似性表明，这些显微镜下不同的病变可能是单个肿瘤克隆扩张的一部分。
Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100% of the carcinomas, in 100% of the adenomas and in 37.5% of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.