Sex-Specific Prevalence of Adenomas, Advanced Adenomas, and Colorectal Cancer in Individuals Undergoing Screening Colonoscopy
Sex-Specific Prevalence of Adenomas, Advanced Adenomas, and Colorectal Cancer in Individuals Undergoing Screening Colonoscopy
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DOI：
10.1001/jama.2011.1362
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发表时间：
2011-09-28
影响因子：
120.7
通讯作者：
Weiss, Werner
中科院分区：
文献类型：
--
作者：
Ferlitsch, Monika;Reinhart, Karoline;Weiss, Werner
背景 虽然一些研究表明男性患晚期结直肠肿瘤的特定年龄风险高于女性，但转诊患者进行结肠镜检查的年龄与性别无关，通常建议为 50 岁。 目的 确定和比较男性和女性不同年龄组的腺瘤、晚期腺瘤 (AA) 和结直肠癌 (CRC) 筛查 (NNS) 的患病率和数量。 设计、设置和患者队列研究 44 名患者奥地利为期 4 年（2007 年至 2010 年）的国家筛查结肠镜检查项目有 350 名参与者。主要结果指标为男性和女性不同年龄组中腺瘤、AA 和 CRC 的患病率和 NNS。结果女性中位年龄为 60.7 岁（四分位距 [IQR]，54.5-67.5 岁），女性为 60.6 岁（IQR，男性的年龄为 54.3-67.6 岁），性别比例几乎相同（51.0% [22 598] vs 49.0% [21 572]）。 19.7% 的筛查个体发现腺瘤（95% CI，19.3%-20.1%；n=8743），AA 占 6.3%（95% CI，6.1%-6.5%；n=2781），CRC 占 1.1%（95% CI，1.0%-1.2%；n=491）； NNS 分别为 5.1（95% CI，5.0-5.2）、15.9（95% CI，15.4-16.5）和 90.9（95% CI，83.3-100.0）。男性与较高的腺瘤患病率显着相关（24.9% [95% CI, 24.3%-25.4%] vs 14.8% [95% CI, 14.3%-15.2%]；P
Context Although some studies have shown that men are at greater age-specific risk for advanced colorectal neoplasia than women, the age for referring patients to screening colonoscopy is independent of sex and usually recommended to be 50 years.Objective To determine and compare the prevalence and number needed to screen (NNS) for adenomas, advanced adenomas (AAs), and colorectal carcinomas (CRCs) for different age groups in men and women.Design, Setting, and Patients Cohort study of 44 350 participants in a national screening colonoscopy program over a 4-year period (2007 to 2010) in Austria.Main Outcome Measures Prevalence and NNS of adenomas, AAs, and CRCs in different age groups for men and women.Results The median ages were 60.7 years (interquartile range [IQR], 54.5-67.5 years) for women and 60.6 years (IQR, 54.3-67.6 years) for men, and the sex ratio was nearly identical (51.0% [22 598] vs 49.0% [21 572]). Adenomas were found in 19.7% of individuals screened (95% CI, 19.3%-20.1%; n=8743), AAs in 6.3% (95% CI, 6.1%-6.5%; n=2781), and CRCs in 1.1% (95% CI, 1.0%-1.2%; n=491); NNS were 5.1 (95% CI, 5.0-5.2), 15.9 (95% CI, 15.4-16.5), and 90.9 (95% CI, 83.3-100.0), respectively. Male sex was significantly associated with a higher prevalence of adenomas (24.9% [95% CI, 24.3%-25.4%] vs 14.8% [95% CI, 14.3%-15.2%]; P