Stages in spheronisation: evolution of pellet size and shape during spheronisation of microcrystalline cellulose-based paste extrudates
Stages in spheronisation: evolution of pellet size and shape during spheronisation of microcrystalline cellulose-based paste extrudates
复制标题
滚圆阶段：基于微晶纤维素的糊状挤出物滚圆过程中颗粒尺寸和形状的演变
DOI：
10.1016/j.powtec.2014.10.014
复制
发表时间：
2015
影响因子：
5.2
通讯作者：
D. I. Wilson
中科院分区：
文献类型：
--
作者：
M. Bryan;L. Atherton;S. Duffield;S. L. Rough;D. I. Wilson
使用Lau等人（2014）报告的中断技术，研究了MCC/水糊剂和一些MCC/水/碳酸钙糊剂的挤出物破碎和圆化阶段，以形成球状颗粒。一个新的定量参数，命名为“哑铃”，被开发用于监测“哑铃”形球团的形成和消失在成圆过程的早期阶段。使用有色挤出物的混合物的测试证实，小碎片（“细粉”）附着到粒料的腰部不是从哑铃形转变为更球形的原因。结果证实了Lau等人的发现，四舍五入是速率限制步骤。用最多20重量%碳酸钙（代表硬的活性药物成分的碳酸盐）经历相同的滚圆机理。球化含碳酸盐糊剂的时间较长，这可能与这些材料的抗变形性增加有关。
The stages of extrudate breakup and rounding to form spheroidal pellets were investigated for MCC/water pastes and some MCC/water/calcium carbonate pastes using the interrupted technique reported by Lau et al. (2014). A new quantitative parameter, named ‘dumb-bellity’, was developed to monitor the formation and disappearance of ‘dumb-bell’ shaped pellets in the early stages of the rounding process. Tests using mixtures of coloured extrudates confirmed that attachment of small fragments (‘fines’) to the waist of pellets was not responsible for the transition from dumb-bell to more spheroidal shapes. The results confirmed the findings of Lau et al., that rounding was the rate-limiting step. Extrudates prepared with up to 20 wt.% calcium carbonate, (the carbonate representing a hard, active pharmaceutical ingredient), were subject to the same spheronisation mechanism. The time to spheronise the carbonate-containing pastes was longer, which could be related to the increased deformation resistance of these materials.