Rapid Ullmann-type synthesis of aryl sulfides using a copper(I) catalyst and ligand under microwave irradiation
Rapid Ullmann-type synthesis of aryl sulfides using a copper(I) catalyst and ligand under microwave irradiation
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DOI：
10.1016/j.tetlet.2009.03.115
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发表时间：
2009-07-01
影响因子：
1.8
通讯作者：
Fusillo, Vincenzo
中科院分区：
文献类型：
--
作者：
Bagley, Mark C.;Dix, Matthew C.;Fusillo, Vincenzo
报道了一种在微波辐射下快速有效地形成C-S键的方法。以K(2)CO(3)为碱，在2-丙醇中加入2等量的反式环己烷-1,2-二醇作为配体，促进了富电子和贫电子芳基卤化物与硫醇的反应。微波在120℃下照射3小时，得到相应的芳基硫化物，程序适用于文库生产。2009爱思唯尔有限公司版权所有。
A rapid and efficient method for C-S bond formation under microwave irradiation is reported. The reaction of both electron-rich and electron-poor aryl halides with thiols using copper(I) iodide as a catalyst is facilitated by the addition of 2 equiv of trans-cyclohexane-1,2-diol as ligand in the presence Of K(2)CO(3) as base in 2-propanol. Microwave irradiation at 120 degrees C for 3 h gives the corresponding aryl sulfide in a procedure amenable to library production. (C) 2009 Elsevier Ltd. All rights reserved.