Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals.
Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals.
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低密度脂蛋白单采术治疗狼疮性肾炎肾小球内泡沫细胞含有胆固醇晶体的蛋白尿。
DOI：
10.1053/j.ajkd.2014.09.028
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Mukoyama M.
中科院分区：
文献类型：
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作者：
Shiraishi N;Kitamura K;Hayata M;Ogata T;Tajiri-Okamura K;Nakayama Y;Kohda Y;Tomita K;Mukoyama M.
一名28岁女性系统性红斑狼疮患者因肾病水平蛋白尿被转诊至我院，尽管接受了约1年的泼尼松龙50至60 mg/d和环孢素100至150 mg/d联合甲基泼尼松龙冲击治疗。肾活检显示弥漫性全球狼疮性肾炎（世界卫生组织4-G A/C级），肾小球内有许多含有胆固醇晶体的泡沫细胞。令人惊讶的是，蛋白尿减少后，只有5个低密度脂蛋白（LDL）胆固醇单采会议。该病例证明了LDL单采术不仅对局灶节段性肾小球硬化症，而且对其他类型的肾炎，特别是肾小球内泡沫细胞肾炎具有显着影响的潜力。
A 28-year-old woman with systemic lupus erythematosus was referred to our hospital due to nephrotic-level proteinuria despite approximately 1 year of treatment with 50 to 60 mg/d of prednisolone and 100 to 150 mg/d of cyclosporine with methylprednisolone pulse therapy. Kidney biopsy showed diffuse global lupus nephritis (World Health Organization class 4-G A/C) with many intraglomerular foam cells containing cholesterol crystals. Surprisingly, proteinuria diminished after only 5 low-density lipoprotein (LDL) cholesterol apheresis sessions. This case demonstrated the potential of LDL apheresis to exhibit a remarkable effect on not only focal segmental glomerulosclerosis, but also other types of nephritis, particularly nephritis with intraglomerular foam cells.