Tandyukisins E and F, novel cytotoxic decalin derivatives isolated from a marine sponge-derived fungus
Tandyukisins E and F, novel cytotoxic decalin derivatives isolated from a marine sponge-derived fungus
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DOI：
10.1016/j.tetlet.2016.10.004
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发表时间：
2016-11-16
影响因子：
1.8
通讯作者：
Yamada, Takeshi
中科院分区：
文献类型：
--
作者：
Suzue, Mayo;Kikuchi, Takashi;Yamada, Takeshi
Tandyukisins A-D reported previously, novel decalin derivatives, have been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, their chemical structures were established by chemical transformation. In our continuing search for cytotoxic metabolites from this strain, we isolated two new decalin derivatives designated tandyukisins E (1) and F (2). They have unique chemical structures with different side chains from those of tandyukisins obtained so far. In addition, they exhibited significant cytotoxicity against the cancer cell lines P388, HL-60, and L1210. (C) 2016 Elsevier Ltd. All rights reserved.
