Coordinate regulation of complex T cell populations responding to bacterial infection
Coordinate regulation of complex T cell populations responding to bacterial infection
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DOI：
10.1016/s1074-7613(00)80540-3
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发表时间：
1998-03-01
期刊：
影响因子：
32.4
通讯作者：
Pamer, EG
中科院分区：
文献类型：
--
作者：
Busch, DH;Pilip, IM;Pamer, EG
细菌感染会激活大小和抗原特异性不同的复杂 T 细胞群。我们使用与单核细胞增多性李斯特菌衍生表位复合的四聚化 MHC I 类分子来表征细菌感染期间四种不同的 CD8(+) T 淋巴细胞群。令人惊讶的是，抗原特异性不同的 T 细胞群同步扩张、收缩并进入 T 细胞记忆区室。由于四种单核细胞增多性李斯特菌表位在受感染细胞中呈现出不同的效率并具有不同的稳定性，因此我们的研究结果表明这些因素并不决定体内 T 细胞动力学。虽然 T 细胞激活需要抗原呈递，但 T 细胞扩增的时间和程度似乎以独立于抗原数量和稳定性的协调方式进行调节。
Bacterial infections activate complex T cell populations that differ in size and antigen specificity. We used tetramerized MHC class I molecules complexed with Listeria monocytogenes-derived epitopes to characterize four distinct CD8(+) T lymphocyte populations during bacterial infection. Surprisingly, T cell populations differing in antigen specificity expand, contract, and enter the T cell memory compartment synchronously. Because the four L. monocytogenes epitopes are presented with different efficiencies and have distinct stabilities in infected cells, our findings suggest that these factors do not determine in vivo T cell dynamics. While T cell activation requires antigen presentation, the timing and extent of T cell expansion appear to be regulated in a coordinated fashion independent of antigen quantity and stability.