The natural history of halo nevi: A retrospective case series
The natural history of halo nevi: A retrospective case series
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DOI：
10.1016/j.jaad.2011.11.937
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发表时间：
2012-10-01
影响因子：
13.8
通讯作者：
Brodell, Robert T.
中科院分区：
文献类型：
--
作者：
Aouthmany, Mouhammad;Weinstein, Mara;Brodell, Robert T.
背景：从晕状痣（HN）周围色素沉着开始到痣和晕状痣完全消退的时间尚未得到很好的研究。目的：我们试图更好地了解HN的自然历史。方法：对1994-2010年私人诊所数据库中临床诊断为HN的患者进行回顾性分析。总共鉴定出52例80例HN患者。通过对36例56例HN患者的随访问卷和体格检查来确定HN的当前阶段。结果：7例HN切除。在剩余的49例HN中，51%（25例）在平均4.2年后显示光晕或痣没有变化；14.3%(7)的患者在平均6.7年后表现为部分痣消退，晕持续存在；平均7.7年后，有4.1%(2)的患者表现为痣完全消退并伴有持续的光晕色素沉着；8.2%(4)在平均11.8年后表现出完全的痣复旧，晕有一些重新色素沉着；22.4%（11）的患者在平均7.8年后痣完全消退，晕完全恢复色素沉着。局限性：部分受试者未能随访。HN的初始发病时间取决于患者的回忆。结论：这些结果表明HN通常持续10年或更长时间。一个亚组可能会经历复发阶段，恢复正常外观的皮肤，但即使这些病变平均持续7.8年。教育HN的长期自然病史可以使患者放心，避免不必要的切除。[J] .中华皮肤科杂志，2012;67:582-6。
Background: The time period between onset of depigmentation around the halo nevus (HN) to complete resolution of the nevus and halo has not been well studied.Objective: We sought to better understand the natural history of the HN.Methods: A retrospective chart review of patients with a clinical diagnosis of HN selected from a private practice database (1994-2010) was performed. In all, 52 patients with 80 HN were identified. The current stage of the HN was determined by a follow-up questionnaire and physical examination of 36 patients with 56 HN.Results: Seven HN were excised. Of the remaining 49 HN, 51% (25) demonstrated no change in the halo or nevus after an average of 4.2 years; 14.3% (7) demonstrated partial nevus regression with persistence of the halo after an average of 6.7 years; 4.1% (2) demonstrated complete involution of the nevus with persistent halo depigmentation after an average of 7.7 years; 8.2% (4) demonstrated complete nevus involution with some repigmentation of the halo after an average of 11.8 years; 22.4% (11) demonstrated complete resolution of the nevus with complete repigmentation of the halo after an average of 7.8 years.Limitation: Some subjects were lost to follow-up. The time of initial HN onset was dependent on patient recall.Conclusion: These results demonstrate that HN typically persist for a decade or longer. A subgroup may progress through stages of involution with a return to normal-appearing skin, but even these lesions persisted for an average of 7.8 years. Education about the prolonged natural history of HN may reassure patients and avoid unnecessary excision. (J Am Acad Dermatol 2012;67:582-6.)