A PROPOSED AUTACOID MECHANISM CONTROLLING MASTOCYTE BEHAVIOR
A PROPOSED AUTACOID MECHANISM CONTROLLING MASTOCYTE BEHAVIOR
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DOI：
10.1007/bf01972748
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发表时间：
1993-01-01
期刊：
影响因子：
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通讯作者：
LEVIMONTALCINI, R
中科院分区：
文献类型：
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作者：
ALOE, L;LEON, A;LEVIMONTALCINI, R
本研究提供的证据支持体内存在一种新的调节性肥大细胞对伤害性刺激的负性调节机制，因此命名为“澳门样局部炎症拮抗剂”(Alia)。特别是，由于N-酰基乙醇胺类型的脂酰胺已被报道在退行性炎症条件下在组织中积聚，我们研究了这些N-酰化脂类在体内是否对肥大细胞的激活起到调节作用。结果表明，长链和短链N-乙酰乙醇胺全身给药后，均能有效地减轻发育期大鼠耳廓局部注射P物质引起的肥大细胞脱颗粒。这些和其他数据表明，内源性N-乙醇胺的产生可能构成了肥大细胞对各种激活信号的负反馈控制的局部自分泌/旁分泌反应。这一过程可能在调节功能性神经免疫-肥大细胞相互作用中具有生理和病理意义。
Evidence is provided here supporting the existence of a novel autacoid mechanism negatively modulating mast cell behaviour in response to noxious stimuli in vivo; hence, the denomination ''autacoid local inflammation antagonism'' (ALIA). In particular, as lipid amides of the N-acylethanolamine type have been reported to accumulate in tissues in degenerative inflammatory conditions, we examined whether these N-acylated lipids could exert regulatory effects on mast cell activation in vivo. The results reported show that both long- and short-chain N-acylethanolamines, when systemically administered, are effective in reducing mast cell degranulation induced by local injection of substance P in the ear pinna of developing rats. These and other data suggest that the endogenous production of N-acylethanolamines may constitute a local autocrine/paracrine response for the negative feedback control of mast cell responses to various activating signals. Such a process may be of physio-pathological relevance in the regulation of functional neuroimmune-mast cell interactions.