Overview of ovarian follicular development: Considerations for the toxicologist
Overview of ovarian follicular development: Considerations for the toxicologist
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DOI：
10.1002/(sici)1098-2280(1997)29:1
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发表时间：
1997
影响因子：
2.8
通讯作者：
A. Hirshfield
中科院分区：
文献类型：
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作者：
A. Hirshfield
卵泡发生是一个漫长的过程，导致产生物种特异性的，高度一致数量的卵泡，这些卵泡在每个生殖周期中恰好在排卵的适当时间成熟。卵泡发生的某些特征可能对毒理学家研究环境诱变剂对卵母细胞的影响具有特殊意义。这些特征包括卵泡不断变化的几何形状，发育中的卵泡过多（其中大多数将退化而不是排卵），卵泡生长的指数性质，随着卵泡大小的增加细胞增殖的加速，以及发育过程倒数第二阶段的主要反馈调节步骤的位置。因为卵巢可以在短期内对内稳态的丧失做出快速和完全的反应，所以毒性损伤可能不明显。然而，长期生育能力可能会受到损害。卵泡池的有限大小和卵泡生长早期缺乏反馈调节步骤，使卵巢无法恢复中小型卵泡的现状。这最终会导致对成熟卵泡数量和生殖周期规律性的精细控制丧失，并可能减少可育寿命的总体持续时间。Environ.摩尔变异体29：10-15，1997 © 1997 Wiley利斯公司
Folliculogenesis is the lengthy process that results in the production of a species‐specific, highly consistent number of follicles, which ripen during each reproductive cycle at precisely the appropriate time for ovulation. Certain features of folliculogenesis may have special implications for toxicologists studying effects of environmental mutagens on oocytes. Such features include the constantly changing geometry of the ovarian follicle, the great excess of developing follicles (most of which will degenerate rather than ovulate), the exponential nature of follicular growth, the acceleration of cell proliferation as follicular size increases, and the location of the principal feedback regulatory step at the penultimate stage of the developmental process. Because the ovary can respond quickly and completely to loss of homeostasis over the short term, damage from toxic insult may not be readily apparent. However, long‐range fertility may nevertheless be impaired. The finite size of the follicular pool and the absence of feedback regulatory steps during the early stages of follicular growth render the ovary incapable of restoring the status quo among small and medium‐sized follicles. This will eventually result in loss of fine control over the number of follicles that ripen and the regularity of the reproductive cycles and could reduce the overall duration of the fertile life span. Environ. Mol. Mutagen. 29:10–15, 1997 © 1997 Wiley‐Liss, Inc.