Thresholds of skin sensitivity are partially influenced by mechanical properties of the skin on the foot sole.
Thresholds of skin sensitivity are partially influenced by mechanical properties of the skin on the foot sole.
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DOI：
10.14814/phy2.12425
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发表时间：
2015-06
影响因子：
2.5
通讯作者：
Bent LR
中科院分区：
文献类型：
--
作者：
Strzalkowski ND;Triano JJ;Lam CK;Templeton CA;Bent LR
在整个脚底，有振动和单丝感觉差异，尽管所谓的皮肤传入均匀分布。机械性能的差异跨脚底网站已提出，以说明这些差异。对年轻健康成人（n = 22）的5个足底位置的皮肤硬度、表皮厚度和拉伸反应进行了振动（VPT; 3 Hz、40 Hz、250 Hz）和单丝（MF）感知阈值测量。感知阈值预计与所有机械性能测量相关联，以帮助解决不同地点之间的敏感性差异。根据这一假设，MedArch一直被认为是最薄、最软的部位，并表现出最大的敏感性。相反，脚后跟被发现是最厚和最硬的部位，在知觉测试中相对不敏感。表皮拉伸反应测量没有观察到部位差异。尽管在较硬和较厚的部位有明显的感觉阈值升高的趋势，但敏感性测量和皮肤力学性能之间没有观察到显著的相关性。在年轻健康人群中，皮肤硬度和表皮厚度对VPT的影响可以忽略不计，对MF的影响较小。当将每个变量归一化（大于或小于受试者平均值的百分比）到受试者平均值时，观察到MF与皮肤硬度（R2 = 0.422, P < 0.0001）和表皮厚度（R2 = 0.433, P < 0.0001）之间存在显著正相关，这表明皮肤力学可以影响MF阈值。在年轻健康的成年人中，敏感性的差异存在于整个脚底，但不能仅仅由皮肤机械特性的差异来解释。
Across the foot sole, there are vibration and monofilament sensory differences despite an alleged even distribution of cutaneous afferents. Mechanical property differences across foot sole sites have been proposed to account for these differences. Vibration (VPT; 3 Hz, 40 Hz, 250 Hz), and monofilament (MF) perception threshold measurements were compared with skin hardness, epidermal thickness, and stretch response across five foot sole locations in young healthy adults (n = 22). Perceptual thresholds were expected to correlate with all mechanical property measurements to help address sensitivity differences between sites. Following this hypothesis, the MedArch was consistently found to be the thinnest and softest site and demonstrated the greatest sensitivity. Conversely, the Heel was found to be the thickest and hardest site, and was relatively insensitive across perceptual tests. Site differences were not observed for epidermal stretch response measures. Despite an apparent trend of elevated sensory threshold at harder and thicker sites, significant correlations between sensitivity measures and skin mechanical properties were not observed. Skin hardness and epidermal thickness appeared to have a negligible influence on VPT and minor influence on MF within this young healthy population. When normalized (% greater or smaller than subject mean) to the subject mean for each variable, significant positive correlations were observed between MF and skin hardness (R2 = 0.422, P < 0.0001) and epidermal thickness (R2 = 0.433, P < 0.0001) providing evidence that skin mechanics can influence MF threshold. In young healthy adults, differences in sensitivity are present across the foot sole, but cannot solely be accounted for by differences in the mechanical properties of the skin.